Our research projects are currently funded by:
MNiSW (Ministry of Science and Higher Education - Poland)
FNP (Foundation for Polish Science - Poland)
NIH (National Institutes of Health - USA)
6FP (Framework Programme - EU)

OUR KEY PROJECTS:

- Development of tools for protein structure prediction. We develop software for protein structure prediction from sequence. The pipeline of methods developed in our laboratory, which includes the fold recognition metaserver, modeling tools, and model quality assessment tools is available via the GeneSilico TOOLKIT.

- Development of tools for modeling and analysis of RNA and RNP 3D structures. We develop software for both comparative and de novo modeling of RNA and for prediction of RNA-ligand interactions. Our "flagship" method is ModeRNA, software for comparative modeling of RNA 3D structures.

- Development of databases of nucleic acid metabolism. First, we developed and maintain the MODOMICS database of systems biology of posttrascriptional RNA modification. Currently, we are developing databases of DNA repair pathways, and RNA processing pathways.

- RNA modification enzymes. We predict (using bioinformatics) and characterize experimentally novel RNA modification enzymes, in particular RNA methyltransferases.

- Nucleases. We predict (using bioinformatics) and characterize experimentally novel RNAses and DNases, and we use protein engineering techniques to obtain enzymes with new functions, e.g. restriction enzymes with new substrate speificities.