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Enzymatic Complex Summary

SEN complex from Saccharomyces cerevisiae

Known also as: tRNA-splicing endonuclease
Enzyme type: endonuclease


Structure of SEN complex (Saccharomyces cerevisiae):

 
Protein components:
tRNA-splicing endonuclease subunit SEN2
tRNA-splicing endonuclease subunit SEN54
tRNA-splicing endonuclease subunit SEN15
tRNA-splicing endonuclease subunit SEN34
 

 

FUNCTION:
  1. tRNA-splicing endonuclease complex, which is responsible for identification and cleavage of the splice sites in pre-tRNA (PMID: 16710424)
  2. It's composed of 4 subunits: Sen2, Sen15, Sen34, Sen 54 (PMID: 16710424)
  3. pre-tRNA cleavage at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini(PMID: 16710424)


Reactions in which SEN complex is involved:
Pathways in which SEN complex is involved:
References:

Authors Title Journal
Trotta CR, Paushkin SV, Patel M, Li H, Peltz SW Cleavage of pre-tRNAs by the splicing endonuclease requires a composite active site. Nature 2006-05-18



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Last modification of this entry: Aug. 23, 2012.

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