Welcome! Click here to login or here to register.
Catalytic RNA molecules
Enzymatic complexes
Draw a picture

Bujnicki Lab Homepage

Enzymatic Complex Summary

Exosome from Saccharomyces cerevisiae

Enzyme type: 3'-5'-exoribonuclease

Structure of Exosome (Saccharomyces cerevisiae):

Enzymatic components:
Exosome core
Protein components:
Exosome complex exonuclease RRP6
Exosome complex exonuclease DIS3

Reactions in which Exosome is involved:
Pathways in which Exosome is involved:

Authors Title Journal
Symmons MF, Williams MG, Luisi BF, Jones GH, Carpousis AJ Running rings around RNA: a superfamily of phosphate-dependent RNases. Trends Biochem Sci 2002-02-01
Schmid M, Jensen TH The exosome: a multipurpose RNA-decay machine. Trends Biochem Sci 2008-10-01
Lykke-Andersen S, Tomecki R, Jensen TH, Dziembowski A The eukaryotic RNA exosome: same scaffold but variable catalytic subunits. RNA Biol 2011-02-01
Schaeffer D, van Hoof A... Different nuclease requirements for exosome-mediated degradation of normal and nonstop mRNAs. Proc Natl Acad Sci U S A 2011-01-08
Schneider C, Leung E, Brown J, Tollervey D... The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome. Nucleic Acids Res 2009-03-01

Add your own comment!

There are no comments yet.

Last modification of this entry: 2012-07-05 14:47:56
Edited by a user: kaja
Edited content: Changed publications.

Welcome stranger! Click here to login or here to register.