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Enzymatic Complex Summary |
SURF complex from Homo sapiens
| Known also as: | SMG1-UPF1-eRF1-eRF3 complex |
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Structure of SURF complex (Homo sapiens):
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In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD |
Reactions in which SURF complex is involved:
- Displacement of UPF3 by SMG6 at EJC. in Homo sapiens [reaction id: 49]
- Endonucleolytic cleavage by SMG6 in Homo sapiens [reaction id: 50]
- Forming of SURF complex and binding to stalled ribosome. in Homo sapiens [reaction id: 44]
- UPF1 bridges EJC to terminating ribosome. in Homo sapiens [reaction id: 45]
- Phosphorylation of UPF1 by SMG1 in Homo sapiens [reaction id: 46]
Pathways in which SURF complex is involved:
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Last modification of this entry: May 16, 2012.
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