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Bujnicki Lab Homepage

Enzymatic Complex Summary

SURF complex from Homo sapiens

Known also as: SMG1-UPF1-eRF1-eRF3 complex


Structure of SURF complex (Homo sapiens):

 
Protein components:
Serine/threonine-protein kinase SMG1
Regulator of nonsense transcripts 1
Eukaryotic peptide chain release factor subunit 1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
 

In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD



Reactions in which SURF complex is involved:
Pathways in which SURF complex is involved:


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Last modification of this entry: May 16, 2012.

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