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Catalytic RNA molecules
Enzymatic complexes
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Enzymatic Complex Summary

CstF from Homo sapiens

Known also as: Cleavage stimulatory factor, cleavage stimulation factor

Structure of CstF (Homo sapiens):

Protein components:
Cleavage stimulation factor subunit 1
Cleavage stimulation factor subunit 2
Cleavage stimulation factor subunit 3

Cleavage stimulatory factor or cleavage stimulation factor (CstF or CStF) is a heterotrimeric enzyme, made up of the proteins CSTF1 (55kDa), CSTF2 (64kDa) and CSTF3 (77kDa), totalling about 200 kDa. It is involved in the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA (mRNA) molecule. CstF is recruited by cleavage and polyadenylation specificity factor (CPSF) and assembles into a protein complex on the 3' end to promote the synthesis of a functional polyadenine tail, which results in a mature mRNA molecule ready to be exported from the cell nucleus to the cytosol for translation.

The amount of CstF in a cell is dependent on the phase of the cell cycle, increasing significantly during the transition from G0 phase to S phase in mouse fibroblast and human splenic B cells.

Reactions in which CstF is involved:
Pathways in which CstF is involved:

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Last modification of this entry: Aug. 22, 2012.

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