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Catalytic RNA molecules
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Enzymatic Complex Summary

Ribonuclease P from Homo sapiens

Known also as: RNase P
Enzyme type: endoribonuclease

Structure of Ribonuclease P (Homo sapiens):

Protein components:
Ribonuclease P protein subunit p14
Ribonuclease P protein subunit p20
Ribonuclease P protein subunit p21
Ribonuclease P protein subunit p25
Ribonuclease P protein subunit p29
Ribonuclease P protein subunit p30
Ribonuclease P protein subunit p38
Ribonuclease P protein subunit p40
Ribonucleases P/MRP protein subunit POP1
Ribonuclease P/MRP protein subunit POP5
RNA components:

Human nuclear RNase P consists of 10 Protein subunits and one RNA subunit. Of those, 6 subunit show homoloy to the nuclear RNase P of S. cerevisae

Reactions in which Ribonuclease P is involved:
Pathways in which Ribonuclease P is involved:

Authors Title Journal
Reiner R, Ben-Asouli Y, Krilovetzky I, Jarrous N A role for the catalytic ribonucleoprotein RNase P in RNA polymerase III transcription. Genes Dev 2006-06-15
Puranam RS, Attardi G The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P. Mol Cell Biol 2001-02-01
Mann H, Ben-Asouli Y, Schein A, Moussa S, Jarrous N Eukaryotic RNase P: role of RNA and protein subunits of a primordial catalytic ribonucleoprotein in RNA-based catalysis. Mol Cell 2003-10-01
Kawa D, Wang J, Yuan Y, Liu F Inhibition of viral gene expression by human ribonuclease P. RNA 1998-11-01
Jarrous N Human ribonuclease P: subunits, function, and intranuclear localization. RNA 2002-02-01
Jarrous N, Reiner R Human RNase P: a tRNA-processing enzyme and transcription factor. Nucleic Acids Res 2007-01-01
Evans D, Marquez SM, Pace NR RNase P: interface of the RNA and protein worlds. Trends Biochem Sci 2006-06-01
Altman S The road to RNase P. Nat Struct Biol 2000-10-01
Holzmann J, Frank P, Loffler E, Bennett KL, Gerner C, Rossmanith W RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. Cell 2008-10-31

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Last modification of this entry: 2012-07-05 14:50:54
Edited by a user: kaja
Edited content: Changed publications.

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