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Enzymatic Complex Summary

Ribonuclease P from Saccharomyces cerevisiae

Known also as: RNase P
Enzyme type: endoribonuclease

Structure of Ribonuclease P (Saccharomyces cerevisiae):

Protein components:
Ribonucleases P/MRP protein subunit POP1
Ribonucleases P/MRP protein subunit POP3
Ribonucleases P/MRP protein subunit POP4
Ribonucleases P/MRP protein subunit POP5
Ribonucleases P/MRP protein subunit POP6
Ribonucleases P/MRP protein subunit POP7
Ribonucleases P/MRP protein subunit POP8
Ribonuclease P/MRP protein subunit RPP1
Ribonuclease P protein subunit RPR2
RNA components:

Ribonuclease P (RNase P) is an essential endoribonuclease that acts early in tRNA biogenesis to remove the 5  leader sequences of precursor tRNAs (pre-tRNAs) (PMID: 11880623) and processes precursors of ribosomal RNAs. (PMID: 16618965). Rnase P contains 9 protein and 1 RNA subunits (PMID: 16618965)

The eukaryotic RNase P RNA appears to have lost the ability to cleave pre-tRNAs in the absence of the protein subunits. (PMID: 11880623, 16618965)


Reactions in which Ribonuclease P is involved:
Pathways in which Ribonuclease P is involved:

Authors Title Journal
Holec S, Lange H, Kuhn K, Alioua M, Borner T, Gagliardi D Relaxed transcription in Arabidopsis mitochondria is counterbalanced by RNA stability control mediated by polyadenylation and polynucleotide phosphorylase. Mol Cell Biol 2006-04-01
Walter M, Kilian J, Kudla J PNPase activity determines the efficiency of mRNA 3'-end processing, the degradation of tRNA and the extent of polyadenylation in chloroplasts. EMBO J 2002-12-16
Mann H, Ben-Asouli Y, Schein A, Moussa S, Jarrous N Eukaryotic RNase P: role of RNA and protein subunits of a primordial catalytic ribonucleoprotein in RNA-based catalysis. Mol Cell 2003-10-01
Evans D, Marquez SM, Pace NR RNase P: interface of the RNA and protein worlds. Trends Biochem Sci 2006-06-01

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Last modification of this entry: 2012-07-05 14:51:06
Edited by a user: kaja
Edited content: Changed publications.

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