Welcome! Click here to login or here to register.
Home
Pathways
Proteins
Catalytic RNA molecules
Enzymatic complexes
Structures
Publications
Draw a picture
 
Search
 
Links
Help
Contact





Bujnicki Lab Homepage

NSD in Saccharomyces cerevisiae

Nonstop decay

Proteins:
5'-3' exoribonuclease
Superkiller protein 7
Enzymatic
complexes:
Exosome
Ribosome

NSD in KEGG: sce03015
[picture] [information]



The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These  pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD).

In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end.




alt alt alt alt alt alt alt alt
Add your own comment!

There are no comments yet.

Last modification of this entry: 2012-04-18 13:47:46
Edited by a user: kaja
Edited content: Changed rna_type.

Welcome stranger! Click here to login or here to register.