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Bujnicki Lab Homepage

tRNA maturation in Homo sapiens

Proteins:
CCA tRNA nucleotidyltransferase 1
Zinc phosphodiesterase ELAC protein 2
Enzymatic
complexes:
Ribonuclease P
tRNA ligase complex
tRNA-splicing endonuclease


tRNAs are transcribed by RNA polymerase III as pre-tRNAs in the nucleus. RNA polymerase III recognizes two internal promoter sequences (A-box B internal promoter) inside tRNA genes. The first promoter begins at nucleotide 8 of mature tRNAs and the second promoter is located 30-60 nucleotides downstream of the first promoter. The transcription terminates after a stretch of four or more thymidines.




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Last modification of this entry: 2012-06-21 11:53:43
Edited by a user: kaja
Edited content: Changed reactions and keywords.

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