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mRNA splicing - minor pathway in Homo sapiens

mRNA splicing - minor pathway in KEGG: hsa03040
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mRNA splicing - minor pathway in REACTOME: REACT_1753

The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing. Most of the mRNA is spliced by the major pathway, involving the U1, U2, U4, U5 and U6 snRNPs. A minor fraction, about 1 %, of the mRNAs are spliced via the U12 dependent pathway. [source: REACTOME - REACT_1735.2]

Minor pathway: The splicing of a subset of pre-mRNA introns occurs by a second pathway, designated the AT-AC or U12-dependent splicing pathway. AT-AC introns have highly conserved, non-canonical splice sites that are removed by the AT-AC spliceosome, which contains distinct snRNAs (U11, U12, U4atac, U6atac) that are structurally and functionally analogous to the major spliceosome. U5 snRNA as well as many of the protein factors appear to be conserved between the two spliceosomes. [source: REACTOME - REACT_1753.2]


Information about proteins and complexes taking part in splicing can be found in SpliProt3D or in Spliceosome Database.

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Last modification of this entry: Sept. 18, 2012.

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