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Bujnicki Lab Homepage

tiRNA biogenesis in Homo sapiens

biogenesis of stress-induced tRNA-derived RNAs

Proteins:
Angiogenin


Stress-induced tRNA-derived RNAs (tiRNAs) (named also tRNA halves), found in diverse eukaryotes, are generated by endonucleolytic cleavage in the anticodon loop of mature tRNAs, catalyzed by angiogenin in mammals [PMID: 19332886, 19114040]. Under normal conditions, angiogenin is inhibited by binding to RNH1 [PMID: 19332886].

tRNA cleavage is induced by various stress conditions, such as nutrition deficiency, hypoxia and hypothermia or arsenite, heat shock, or ultraviolet irradiation.




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Last modification of this entry: Aug. 19, 2012.

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