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Bujnicki Lab Homepage

histone mRNA 3' end maturation in Homo sapiens

Proteins:
Histone RNA hairpin-binding protein
Zinc finger protein 473
Enzymatic
complexes:
CPSF
CstF
U7 snRNP


Metazoan histone mRNAs lacking poly(A) tail employ a noncanonical 3'-end processing mechanism dependent on the binding of U7 snRNP, composed of U7 snRNA and the LSm proteins, to the HDE sequence located downstream from the cleavage site. Another element required for histone mRNA processing is the conserved stem-loop upstream of the cleavage site which is bound by the SLBP factor. Cleavage is preceded by an interaction involving SLBP and U7 snRNP, bridged by the zinc- finger protein ZFP100 and utilizing CPSF and possibly also CstF, similarly to the mechanism presented in A. The CPSF-73 subunit is not only responsible for the endonucleolytic cleavage which determines the position of the histone mRNA mature 3' end, but it might also display 5' - 3' exoribonucleolytic activity, allowing for the degradation of the downstream cleavage product. [PMID: 20675404]




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Last modification of this entry: Aug. 21, 2012.

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