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Reaction Summary:

Recruitment of UPF2 protein by UPF3 in Homo sapiens



Exon junction complex (EJC) is the residual 'mark' of splicing, upstream of every exon junction. As most introns are located in coding regions, EJCs are usually displaced by translating ribosomes. But in mRNAs that contain a PTC, the EJC remains inappropriately associated with the mRNA downstream of the PTC, where it is detected by the surveillance machinery. UPF3 then recruits another NMD machinery element - UPF2UPF2 and UPF3 are peripheral components of the EJC and thus may link the EJC to the SURF complex.



This is a reaction from:

mRNA with PTC Preceding Exon Junction bound to Ribosome in Homo sapiens
to
mRNA with PTC Preceding Exon Junction:Ribosome:UPF2 complex in Homo sapiens


in given pathways:

Proteins involved in a given reaction:

Enzymatic complexes involved in a given reaction:




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Last modification of this entry: May 16, 2012.

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