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Reaction Summary:

Forming of SURF complex and binding to stalled ribosome. in Homo sapiens



During a normal translation-termination event, the stop codon is recognized by the peptide-release factors eRF1 and eRF3 leading to peptidyl-transfer RNA (tRNA) hydrolysis. When termination occurs at a PTC, peptide release is delayed and the ribosome remains stalled at the stop codon. This allows binding of UPF1 and the SMG1 kinase to the release factors, forming a copmlex, known as SURF, on the stalled ribosome.



This is a reaction from:

mRNA with PTC Preceding Exon Junction:Ribosome:UPF2:SMGC1 complex in Homo sapiens
to
mRNA with PTC Preceding Exon Junction:Ribosome:UPF2:SMG1C:SURF complex in Homo sapiens


in given pathways:

Proteins involved in a given reaction:

Enzymatic complexes involved in a given reaction:

References:

Authors Title Journal
Garneau NL, Wilusz J, Wilusz CJ The highways and byways of mRNA decay. Nat Rev Mol Cell Biol 2007-01-01




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Last modification of this entry: May 17, 2012.

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