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Reaction Summary:

UPF1 bridges EJC to terminating ribosome. in Homo sapiens



Through binding to UPF2, UPF1 interacts with the EJC, which lies at an exon-exon junction downstream of the termination site. Formation of this bridge between SURF at the ribosome and the EJC leads to phosphorylation of UPF1 by SMG1 and dissociation of the release factors.



This is a reaction from:

mRNA with PTC Preceding Exon Junction:Ribosome:UPF2:SMG1C:SURF complex in Homo sapiens
to
mRNA with EJC connected to terminating ribosome in Homo sapiens


in given pathways:

Proteins involved in a given reaction:

Enzymatic complexes involved in a given reaction:




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Last modification of this entry: May 17, 2012.

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