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Reaction Summary:

Phosphorylation of UPF1 by SMG1 in Homo sapiens



 

While the kinase activity of SMG1 in SURF is silenced by SMG8-SMG9, SMG1 phosphorylates UPF1 once it associates with EJC-bound UPF2.
 


This is a reaction from:

mRNA with EJC connected to terminating ribosome in Homo sapiens
to
mRNA with EJC connected to terminating ribosome with phosphorylated UPF1 in Homo sapiens


in given pathways:

Proteins involved in a given reaction:

Enzymatic complexes involved in a given reaction:

References:

Authors Title Journal
Hwang J, Maquat LE Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question. Curr Opin Genet Dev 2011-08-01




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Last modification of this entry: May 17, 2012.

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