Known also as: Splicing endonuclease of 54 kDa, tRNA-intron endonuclease SEN54
Known abbreviations: SEN54, YPL083C, LPF3C
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. May be required to embody the molecular ruler of the complex.
tRNA splicing endonuclease is a heterotetramer composed of SEN2, SEN15, SEN34 and SEN54. Interacts directly with SEN2.
Nucleus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note: The tRNA splicing endonuclease complex is predominantly associated with the outer membrane of mitochondria, suggesting that tRNA splicing mainly takes place on the mitochondrial surface.
This protein can be a part of a given complexes:
Activities in which tRNA-splicing endonuclease subunit SEN54 is involved:
Pathways in which tRNA-splicing endonuclease subunit SEN54 is involved:
Links to other databases:
TRNA-splicing endonuclease subunit SEN54 (Saccharomyces cerevisiae) is product of expression of
||Publication date (Issue)
|The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
||Bussey H, Storms RK, Ahmed A, Albermann K, Allen E, Ansorge W, Araujo R, Aparicio A, Barrell B, Badcock K, Benes V, Botstein D, Bowman S, Bruckner M, Carpenter J, Cherry JM, Chung E, Churcher C, Coster F, Davis K, Davis RW, Dietrich FS, Delius H, DiPaolo T, Hani J, et al.
|The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases.
||Trotta CR, Miao F, Arn EA, Stevens SW, Ho CK, Rauhut R, Abelson JN
|Global analysis of protein expression in yeast.
||Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS
|Possibility of cytoplasmic pre-tRNA splicing: the yeast tRNA splicing endonuclease mainly localizes on the mitochondria.
||Yoshihisa T, Yunoki-Esaki K, Ohshima C, Tanaka N, Endo T
Mol Biol Cell
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Last modification of this entry: Sept. 25, 2012.