Known also as: Cancer-associated Sm-like, Small nuclear ribonuclear CaSm
Known abbreviations: LSM1, CASM
Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3'-terminal U-tract of U6 snRNA.
Interacts with SLBP. Interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a doughnut shape.
Has elevated expression in pancreatic cancer and in several cancer-derived cell lines.
This protein can be a part of a given complexes:
Activities in which U6 snRNA-associated Sm-like protein LSm1 is involved:
Pathways in which U6 snRNA-associated Sm-like protein LSm1 is involved:
Links to other databases:
U6 snRNA-associated Sm-like protein LSm1 (Homo sapiens) is product of expression of
||Publication date (Issue)
|The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
||Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, K
|Complete sequencing and characterization of 21,243 full-length human cDNAs.
||Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K
|Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin.
||Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B
|Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.
||Mullen TE, Marzluff WF
|Initial characterization of the human central proteome.
||Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol
|CaSm: an Sm-like protein that contributes to the transformed state in cancer cells.
||Schweinfest CW, Graber MW, Chapman JM, Papas TS, Baron PL, Watson DK
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Last modification of this entry: Sept. 25, 2012.