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Sm-like protein LSm1

Known also as: SPB8 protein

Known abbreviations: LSM1, SPB8, YJL124C, J0714


Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step.
Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. The LSm subunits form a seven-membered ring structure with a doughnut shape By similarity. Interacts with PAT1.
Nucleus. Cytoplasm. Cytoplasm › P-body 

This protein can be a part of a given complexes: Activities in which Sm-like protein LSm1 is involved: Pathways in which Sm-like protein LSm1 is involved:

NCBI GI number(s): 6322337
Species: Saccharomyces cerevisiae

Links to other databases:

Database ID Link
Uniprot P47017 P47017
KEGG sce:YJL124C sce:YJL124C
PFAM: PF01423
InterPro: IPR010920
CATH: - -
SCOP: - -

Protein sequence:

Sm-like protein LSm1 (Saccharomyces cerevisiae) is product of expression of LSM1 gene.


Title Authors Journal Publication date (Issue) PubMed ID
Global analysis of protein localization in budding yeast. Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O'Shea EK Nature 2003-10-16 (425) 14562095
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. Galibert F, Alexandraki D, Baur A, Boles E, Chalwatzis N, Chuat JC, Coster F, Cziepluch C, De Haan M, Domdey H, Durand P, Entian KD, Gatius M, Goffeau A, Grivell LA, Hennemann A, Herbert CJ, Heumann K, Hilger F, Hollenberg CP, Huang ME, Jacq C, Jauniaux JC, Katsoulou C, Karpfinger-Hartl L, et al. EMBO J 1996-05-01 (15) 8641269
Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae. Hu Y, Rolfs A, Bhullar B, Murthy TV, Zhu C, Berger MF, Camargo AA, Kelley F, McCarron S, Jepson D, Richardson A, Raphael J, Moreira D, Taycher E, Zuo D, Mohr S, Kane MF, Williamson J, Simpson A, Bulyk ML, Harlow E, Marsischky G, Kolodner RD, LaBaer J Genome Res 2007-04-01 (17) 17322287
Global analysis of protein expression in yeast. Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS Nature 2003-10-16 (425) 14562106
A Sm-like protein complex that participates in mRNA degradation. Bouveret E, Rigaut G, Shevchenko A, Wilm M, Seraphin B EMBO J 2000-04-03 (19) 10747033
Yeast Sm-like proteins function in mRNA decapping and decay. Tharun S, He W, Mayes AE, Lennertz P, Beggs JD, Parker R Nature 2000-03-01 (404) 10761922
Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19 open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14, RPE1, PHO86, NCA3, ASF1, CCT7, GZF3, two tRNA genes, three remnant delta elements and a Ty4 transposon. Cziepluch C, Kordes E, Pujol A, Jauniaux JC Yeast 1996-11-01 (12) 8948101
Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant. Boeck R, Lapeyre B, Brown CE, Sachs AB Mol Cell Biol 1998-09-01 (18) 9710590
The two proteins Pat1p (Mrt1p) and Spb8p interact in vivo, are required for mRNA decay, and are functionally linked to Pab1p. Bonnerot C, Boeck R, Lapeyre B Mol Cell Biol 2000-08-01 (20) 10913177

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Last modification of this entry: Sept. 25, 2012.

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