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Apoptotic chromatin condensation inducer in the nucleus |
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FUNCTION:
Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.
SUBUNIT STRUCTURE:
Found in a mRNA splicing-dependent exon junction complex (EJC), at least composed of ACIN1, CASC3, EIF4A3, MAGOH, PNN, RBM8A, RNPS1, SAP18 and ALYREF/THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Interacts with API5. Interacts with SRPK2 in a phosphorylation-dependent manner.
CELLULAR LOCALIZATION:
Nucleus. Nucleus speckle. Nucleus › nucleoplasm. Note: Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.
TISSUE SPECIFICITY:
Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.
POST-TRANSLATIONAL MODIFICATION:
Phosphorylation on Ser-1180 by SRPK2 up-regulates its stimulatory effect on cyclin A1.
Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.
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This protein can be a part of a given complexes: Activities in which Apoptotic chromatin condensation inducer in the nucleus is involved:
- mRNP with a Termination Codon Preceding an Exon Junction Complex export from nucleus to cytoplasm in Homo sapiens [reaction id: 41]
- Binding of Ribosome and Translation in Homo sapiens [reaction id: 42]
- Recruitment of UPF2 protein by UPF3 in Homo sapiens [reaction id: 43]
- Forming of SURF complex and binding to stalled ribosome. in Homo sapiens [reaction id: 44]
- UPF1 bridges EJC to terminating ribosome. in Homo sapiens [reaction id: 45]
- Phosphorylation of UPF1 by SMG1 in Homo sapiens [reaction id: 46]
- Forming of SMG1C complex and binding to stalled ribosome. in Homo sapiens [reaction id: 47]
- Binding of SMG5, SMG7 and PP2A to phosphorylated UPF1, dissaciation of release factors. in Homo sapiens [reaction id: 48]
- Displacement of UPF3 by SMG6 at EJC. in Homo sapiens [reaction id: 49]
- Endonucleolytic cleavage by SMG6 in Homo sapiens [reaction id: 50]
- Dephosphorylation of UPF1 by PP2A protein in Homo sapiens [reaction id: 52]
- UPF1 ATPase-dependent mRNA disassembly in Homo sapiens [reaction id: 53]
- Binding of XRN1 to 3'-cleveage product in Homo sapiens [reaction id: 54]
- 5' to 3' Exoribonuclease Cleavage of mRNA in Homo sapiens [reaction id: 55]
- Binding of Exosome Complex to Deadenylated mRNA in Homo sapiens [reaction id: 158]
| NCBI GI number(s): |
259906018 259906017 259906020 259906019 259906022 259906021 259906024 259906023 7662238 190341058 |
| Species: | Homo sapiens |
Links to other databases:
| Database | ID | Link |
|---|---|---|
| Uniprot | Q9UKV3 | Q9UKV3 |
| BRENDA | - | - |
| KEGG | hsa:22985 | hsa:22985 |
| PFAM: |
PF02037 |
PF02037 |
| InterPro: |
IPR012677 IPR000504 IPR003034 |
IPR012677 IPR000504 IPR003034 |
| CATH: | - | - |
| SCOP: | - | - |
Protein sequence:
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MWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVG TDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVK RLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQ RLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSR HSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEE DQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPI LKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKS HLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKAS LVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPAVLI QLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESV LPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQP SLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSG SRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASS NSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTS SSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSE TQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDD RPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRR WGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISED ETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPV PPQVSVEVALPPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTA QVPSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTLVEEAFWIDKIKS HCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELDYHRGLLV DRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAERE REMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKE KAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREK RRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRG DRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR |
Apoptotic chromatin condensation inducer in the nucleus (Homo sapiens) is product of expression of ACIN1 gene.
References:
| Title | Authors | Journal | Publication date (Issue) | PubMed ID |
|---|---|---|---|---|
| The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, K | Genome Res | 2004-10-01 (14) | 15489334 |
| Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. | Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y | Nature | 1999-09-09 (401) | 10490026 |
| A probability-based approach for high-throughput protein phosphorylation analysis and site localization. | Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP | Nat Biotechnol | 2006-10-01 (24) | 16964243 |
| Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | Cell | 2006-11-03 (127) | 17081983 |
| Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. | Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S | Anal Chem | 2009-06-01 (81) | 19413330 |
| Initial characterization of the human central proteome. | Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J | BMC Syst Biol | 2011-01-01 (5) | 21269460 |
| The full-ORF clone resource of the German cDNA Consortium. | Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I | BMC Genomics | 2007-01-01 (8) | 17974005 |
| Lysine acetylation targets protein complexes and co-regulates major cellular functions. | Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M | Science | 2009-08-14 (325) | 19608861 |
| A quantitative atlas of mitotic phosphorylation. | Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP | Proc Natl Acad Sci U S A | 2008-08-05 (105) | 18669648 |
| Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. | Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK | Sci Signal | 2009-01-01 (2) | 19690332 |
| Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. | Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd | J Proteome Res | 2008-03-01 (7) | 18220336 |
| Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. | Tange TO, Shibuya T, Jurica MS, Moore MJ | RNA | 2005-12-01 (11) | 16314458 |
| The DNA sequence and analysis of human chromosome 14. | Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A | Nature | 2003-01-06 (421) | 12508121 |
| Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. | Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | DNA Res | 1998-06-01 (5) | 9734811 |
| Large-scale characterization of HeLa cell nuclear phosphoproteins. | Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP | Proc Natl Acad Sci U S A | 2004-08-17 (101) | 15302935 |
| Global phosphoproteome of HT-29 human colon adenocarcinoma cells. | Kim JE, Tannenbaum SR, White FM | J Proteome Res | 2005-01-01 (4) | 16083285 |
| Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. | Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD | J Proteome Res | 2007-11-01 (6) | 17924679 |
| Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. | Molina H, Horn DM, Tang N, Mathivanan S, Pandey A | Proc Natl Acad Sci U S A | 2007-01-13 (104) | 17287340 |
| Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. | Denis NJ, Vasilescu J, Lambert JP, Smith JC, Figeys D | Proteomics | 2007-03-01 (7) | 17370265 |
| Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis. | Wang B, Malik R, Nigg EA, Korner R | Anal Chem | 2008-12-15 (80) | 19007248 |
| Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. | Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y | Anal Sci | 2008-02-01 (24) | 18187866 |
| Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1. | Jang SW, Yang SJ, Ehlen A, Dong S, Khoury H, Chen J, Persson JL, Ye K | Cancer Res | 2008-06-15 (68) | 18559500 |
| Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. | Carrascal M, Ovelleiro D, Casas V, Gay M, Abian J | J Proteome Res | 2008-12-01 (7) | 19367720 |
| Protein lysine methyltransferase G9a acts on non-histone targets. | Rathert P, Dhayalan A, Murakami M, Zhang X, Tamas R, Jurkowska R, Komatsu Y, Shinkai Y, Cheng X, Jeltsch A | Nat Chem Biol | 2008-06-01 (4) | 18438403 |
| Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. | Han G, Ye M, Zhou H, Jiang X, Feng S, Jiang X, Tian R, Wan D, Zou H, Gu J | Proteomics | 2008-04-01 (8) | 18318008 |
| The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation. | Rigou P, Piddubnyak V, Faye A, Rain JC, Michel L, Calvo F, Poyet JL | EMBO J | 2009-06-03 (28) | 19387494 |
| The consensus coding sequences of human breast and colorectal cancers. | Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE | Science | 2006-10-13 (314) | 16959974 |
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Last modification of this entry: Sept. 25, 2012.
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