Known also as: 18 kDa Sin3-associated polypeptide,2HOR0202,Cell growth-inhibiting gene 38 protein,Sin3-associated polypeptide p18,
Known abbreviations: SAP18, GIG38
Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.
Found in a mRNA splicing-dependent exon junction complex (EJC), at least composed of ACIN1, CASC3, EIF4A3, MAGOH, PNN, RBM8A, RNPS1, SAP18 and ALYREF/THOC4. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Forms a complex with SIN3A and HDAC1.
Nucleus. Cytoplasm. Note: Shuttles between the nucleus and the cytoplasm.
This protein can be a part of a given complexes:
Activities in which Histone deacetylase complex subunit SAP18 is involved:
Pathways in which Histone deacetylase complex subunit SAP18 is involved:
Links to other databases:
Histone deacetylase complex subunit SAP18 (Homo sapiens) is product of expression of
||Publication date (Issue)
|The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
||Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, K
|Complete sequencing and characterization of 21,243 full-length human cDNAs.
||Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K
|Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.
||Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D
|The DNA sequence and analysis of human chromosome 13.
||Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S
|Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
||Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
|Initial characterization of the human central proteome.
||Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol
|Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
||Tange TO, Shibuya T, Jurica MS, Moore MJ
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Last modification of this entry: Sept. 25, 2012.