Known also as: (Di)nucleoside polyphosphate hydrolase, Ap5A pyrophosphatase
Known abbreviations: rppH,nudH, ygdP,b2830, JW2798
Master regulator of 5'-dependent mRNA decay. Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. Preferentially hydrolyzes diadenosine penta-phosphate with ATP as one of the reaction products. Also able to hydrolyze diadenosine hexa- and tetra-phosphate. Has no activity on diadenosine tri-phosphate, ADP-ribose, NADH and UDP-glucose. In the meningitis causing strain E.coli K1, has been shown to play a role in HBMEC (human brain microvascular endothelial cells) invasion in vitro.
Magnesium or zinc. Manganese can be used to a lesser extent.
Activities in which RNA pyrophosphohydrolase is involved:
Pathways in which RNA pyrophosphohydrolase is involved:
Links to other databases:
RNA pyrophosphohydrolase (Escherichia coli) is product of expression of
||Publication date (Issue)
|The complete genome sequence of Escherichia coli K-12.
||Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y
|Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
||Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T
Mol Syst Biol
|The gene ygdP, associated with the invasiveness of Escherichia coli K1, designates a Nudix hydrolase, Orf176, active on adenosine (5')-pentaphospho-(5')-adenosine (Ap5A).
||Bessman MJ, Walsh JD, Dunn CA, Swaminathan J, Weldon JE, Shen J
J Biol Chem
|Identification of Escherichia coli K1 genes contributing to human brain microvascular endothelial cell invasion by differential fluorescence induction.
||Badger JL, Wass CA, Kim KS
|The bacterial enzyme RppH triggers messenger RNA degradation by 5' pyrophosphate removal.
||Deana A, Celesnik H, Belasco JG
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Last modification of this entry: Sept. 25, 2012.