Known also as: La autoantigen homolog, La ribonucleoprotein
Known abbreviations: LHP1, LAH1, YLA1, YDL051W
Molecular chaperone that binds nascent RNA polymerase III transcripts, stabilizing these RNAs against exonucleases. Required for the 3' endonucleolytic cleavage that matures tRNA precursors and for efficient folding of certain pre-tRNAs. Cooperaes with GCD14 in the maturation of a subset of RNA polymerase III transcripts. Functions also in the assembly of certain RNA polymerase II-transcribed RNAs into RNPs. Binds and stabilizes newly synthesized U6 snRNA as well as precursors of U3 snRNA from degradation. Facilitates efficient Sm protein binding, thus assisting formation of the U4/U6 snRNP. Required fot Ty3 normal transposition frequency.
Interacts with SXM1.
Nucleus. Note: Imported into nucleus by the nuclear transport factor SXM1.
Phosphorylation is not required for the roles tRNA and snRNP biogenesis.
Activities in which La protein homolog is involved:
Pathways in which La protein homolog is involved:
Links to other databases:
La protein homolog (Saccharomyces cerevisiae) is product of expression of
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Last modification of this entry: Sept. 25, 2012.