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Known also as: Exosome component 6, mRNA transport regulator 3 homolog, p11
Known abbreviations: hMtr3, EXOSC6
FUNCTION:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. br/>
SUBUNIT STRUCTURE:
Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure.
CELLULAR LOCALIZATION:
Cytoplasm Probable. Nucleus › nucleolus (Probable). Nucleus (Probable).
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This protein can be a part of a given complexes:
Links to other databases:
Protein sequence:
MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAK
GSAYLEAGGTKVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDF
RRAPFAGRRRRAPPGGCEERELALALQEALEPAVRLGRYPRAQLEVSALL
LEDGGSALAAALTAAALALADAGVEMYDLVVGCGLSLAPGPAPTWLLDPT
RLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTESWAEAVRLGLEGCQR
LYPVLQQSLVRAARRRGAAAQP
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Exosome complex component MTR3 (Homo sapiens) is product of expression of
EXOSC6 exosome component 6
gene.
Exosome complex component MTR3 (Homo sapiens) belongs to following protein families:
References:
Title |
Authors |
Journal
| Publication date (Issue)
| PubMed ID
|
Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. |
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ |
J Mol Biol
|
2002-11-01 (323) |
12419256 |
Three novel components of the human exosome. |
Brouwer R, Allmang C, Raijmakers R, van Aarssen Y, Egberts WV, Petfalski E, van Venrooij WJ, Tollervey D, Pruijn GJ |
J Biol Chem
|
2001-03-02 (276) |
11110791 |
A protein interaction framework for human mRNA degradation. |
Lehner B, Sanderson CM |
Genome Res
|
2004-07-01 (14) |
15231747 |
Reconstitution, activities, and structure of the eukaryotic RNA exosome. |
Liu Q, Greimann JC, Lima CD |
Cell
|
2006-12-15 (127) |
17174896 |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, K |
Genome Res
|
2004-10-01 (14) |
15489334 |
AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. |
Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M |
Cell
|
2001-11-16 (107) |
11719186 |
Initial characterization of the human central proteome. |
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J |
BMC Syst Biol
|
2011-01-01 (5) |
21269460 |
The sequence and analysis of duplication-rich human chromosome 16. |
Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M |
Nature
|
2004-12-23 (432) |
15616553 |
Dis3-like 1: a novel exoribonuclease associated with the human exosome. |
Staals RH, Bronkhorst AW, Schilders G, Slomovic S, Schuster G, Heck AJ, Raijmakers R, Pruijn GJ |
EMBO J
|
2010-07-21 (29) |
20531389 |
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. |
Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW |
Cell
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2011-01-04 (144) |
21255825 |
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Last modification of this entry: Sept. 25, 2012.
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