Known also as: Estrogen-regulated transcript 45 protein, Promyelocytic leukemia nuclear body-associated protein ISG20
Known abbreviations: ISG20, HEM45
Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses.
Besides its function in antiviral defense, ISG20 may play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
Binds 2 manganese ions per subunit.
Associates with PML and SP100 in the PML NB complex.
Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung.
Induced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased expression was seen at the transcriptional level. Ref.1 Ref.6
Links to other databases:
Interferon-stimulated gene 20 kDa protein (Homo sapiens) is product of expression of
ISG20 interferon stimulated exonuclease gene 20kDa
Interferon-stimulated gene 20 kDa protein (Homo sapiens) belongs to following protein families:
||Publication date (Issue)
|ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses.
||Espert L, Degols G, Gongora C, Blondel D, Williams BR, Silverman RH, Mechti N
J Biol Chem
|Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1.
||Espert L, Degols G, Lin YL, Vincent T, Benkirane M, Mechti N
J Gen Virol
|The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes.
||Espert L, Eldin P, Gongora C, Bayard B, Harper F, Chelbi-Alix MK, Bertrand E, Degols G, Mechti N
J Cell Biochem
|The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro.
||Nguyen LH, Espert L, Mechti N, Wilson DM 3rd
|ISG20, an actor of the innate immune response.
||Degols G, Eldin P, Mechti N.
|The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
||Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, K
|Expression and estrogen regulation of the HEM45 MRNA in human tumor lines and in the rat uterus.
J Steroid Biochem Mol Biol
|Initial characterization of the human central proteome.
||Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol
|Molecular cloning of a new interferon-induced PML nuclear body-associated protein.
||Gongora C, David G, Pintard L, Tissot C, Hua TD, Dejean A, Mechti N
J Biol Chem
|Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease.
||Horio T, Murai M, Inoue T, Hamasaki T, Tanaka T, Ohgi T
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Last modification of this entry: Sept. 25, 2012.