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Bujnicki Lab Homepage

Gene: LSM4

On chromosome: 19p13.11
Known also as: LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Known abbreviations: GRP, YER112W


NCBI GeneID 25804
NCBI Ensembl Id: ENSG00000130520
Species: Homo sapiens

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Title Authors Journal Publication date (Issue) PubMed ID
A protein interaction framework for human mRNA degradation. Lehner B, Sanderson CM Genome Res 2004-07-01 (14) 15231747
Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B EMBO J 1999-06-15 (18) 10369684
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C Gut 2009-08-01 (58) 19240061
LSm4 associates with the plasma membrane and acts as a co-factor in cell volume regulation. Gandini R, Dossena S, Vezzoli V, Tamplenizza M, Salvioni E, Ritter M, Paulmichl M, Furst J Cell Physiol Biochem 2008-01-01 (22) 19088440


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Last modification of this entry: Aug. 22, 2012.

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