FUNCTION:
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Component of RNase MRP (which cleaves pre-rRNA complexes and mRNA in its 5' untranslated region - UTR) (PMID: 14729943)
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pre-rRNA processing at site A3 in the Interna Transcribed Spacer 1 (ITS1) (participation in synthesis of short form of 5.8S rRNA - 5.8S(S) ) (PMID: 16618965, 9620854, 8247008)
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regulation of the cell cycle through the degradation of specific mRNAs (PMID: 14729943)
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This RNA molecule can be a part of a given complexes:
Reactions in which NME1 is involved:
Pathways in which NME1 is involved:
NME1 (Saccharomyces cerevisiae) belongs to following protein families:
RNA sequence:
AAUCCAUGACCAAAGAAUCGUCACAAAUCGAAGCUUACAAAAUGGAGUAA
AAUUUUUUUUACUCAGUAAUAUGCUUUGGGUUGAAAGUCUCCCACCAAUU
CGUAUGCGGAAAACGUAAUGAGAUUUAAAAAUUUUAAAUUGUUUAAAUCA
ACUCAUUAAGGAGGAUGCCCUUGGGUAUUCUGCUUCUUGACCUGGUACCU
CUAUUGCAGGGUACUGGUGUUUUCUUCGGUACUGGAUUCCGUUUGUAUGG
AAUCUAAACCAUAGUUAUGACGAUUGCUCUUUCCCGUGCUGGAUCGAGUA
ACCCAAUGGAGCUUACUAUUCUUGGUCCAUGGAUUCACCC
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References:
Authors
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Title
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Journal
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Schmitt ME, Clayton DA
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Nuclear RNase MRP is required for correct processing of pre-5.8S rRNA in Saccharomyces cerevisiae.
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Mol Cell Biol
1993-12-01
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Chamberlain JR, Lee Y, Lane WS, Engelke DR
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Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP.
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Genes Dev
1998-06-01
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Gill T, Cai T, Aulds J, Wierzbicki S, Schmitt ME
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RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation.
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Mol Cell Biol
2004-01-01
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Xiao S, Hsieh J, Nugent RL, Coughlin DJ, Fierke CA, Engelke DR
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Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP.
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RNA
2006-06-01
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Last modification of this entry: 2012-04-20 14:14:09
Edited by a user: kaja
Edited content: No fields changed.
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