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NME1

NCBI GI number:	4037	RFAM id:	RF00030
Species:	Saccharomyces cerevisiae

FUNCTION:

Component of RNase MRP (which cleaves pre-rRNA complexes and mRNA in its 5' untranslated region - UTR) (PMID: 14729943)
pre-rRNA processing at site A3 in the Interna Transcribed Spacer 1 (ITS1) (participation in synthesis of short form of 5.8S rRNA - 5.8S(S) ) (PMID: 16618965, 9620854, 8247008)
regulation of the cell cycle through the degradation of specific mRNAs (PMID: 14729943)

This RNA molecule can be a part of a given complexes:

Ribonuclease MRP

Reactions in which NME1 is involved:

Pathways in which NME1 is involved:

rRNA maturation in Saccharomyces cerevisiae

NME1 (Saccharomyces cerevisiae) belongs to following protein families:

RNase_MRP

RNA sequence:

	
	AAUCCAUGACCAAAGAAUCGUCACAAAUCGAAGCUUACAAAAUGGAGUAA

	AAUUUUUUUUACUCAGUAAUAUGCUUUGGGUUGAAAGUCUCCCACCAAUU

	CGUAUGCGGAAAACGUAAUGAGAUUUAAAAAUUUUAAAUUGUUUAAAUCA

	ACUCAUUAAGGAGGAUGCCCUUGGGUAUUCUGCUUCUUGACCUGGUACCU

	CUAUUGCAGGGUACUGGUGUUUUCUUCGGUACUGGAUUCCGUUUGUAUGG

	AAUCUAAACCAUAGUUAUGACGAUUGCUCUUUCCCGUGCUGGAUCGAGUA

	ACCCAAUGGAGCUUACUAUUCUUGGUCCAUGGAUUCACCC

References:

Authors	Title	Journal
Schmitt ME, Clayton DA	Nuclear RNase MRP is required for correct processing of pre-5.8S rRNA in Saccharomyces cerevisiae.	Mol Cell Biol 1993-12-01
Chamberlain JR, Lee Y, Lane WS, Engelke DR	Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP.	Genes Dev 1998-06-01
Gill T, Cai T, Aulds J, Wierzbicki S, Schmitt ME	RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation.	Mol Cell Biol 2004-01-01
Xiao S, Hsieh J, Nugent RL, Coughlin DJ, Fierke CA, Engelke DR	Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP.	RNA 2006-06-01

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Last modification of this entry: 2012-04-20 14:14:09
Edited by a user: kaja
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