Modomics - A Database of RNA Modifications

ID Card:

Full name: Pseudouridylate synthase RPUSD2
Synonym: RPUSD2
UniProt: Q8IZ73
Alpha Fold Predicted Structure: AF-Q8IZ73-F1
Enzyme type: isomerase



Protein sequence:

MWLDRRGWLRVLGHWRYDLRRPSFTRTWSGDKGPMAETVSTQVGTEGGLRASHQQNGDAGGDAKVELSPGPPKPAGREVEPAPVGGEHPSAAAPGPGKHKKRRGATRERVVPPPKKRRTGVSFGDEHFAETSYYFEGGLRKVRPYYFDFRTYCKGRWVGHSLLHVFSTEFRAQPLAYYEAAVRAGRLQLNEKPVQDLNIVLKDNDFLRNTVHRHEPPVTAEPIRLLAENEDVVVVDKPSSIPVHPCGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGVLMFAKTAAVSERIHEQVRDRQLEKEYVCRVEGEFPTEEVTCKEPILVVSYKVGVCRVDPRGKPCETVFQRLSYNGQSSVVRCRPLTGRTHQIRVHLQFLGHPILNDPIYNSVAWGPSRGRGGYIPKTNEELLRDLVAEHQAKQSLDVLDLCEGDLSPGLTDSTAPSSELGKDDLEELAAAAQKMEEVAEAAPQELDTIALASEKAVETDVMNQETDPLCAECRLVRQDPLPQDLVMFLHALRYKGPGFEYFSPMPAWAQDDWQKD

Comments:





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M W L D R R G W L R V L G H W R Y D L R R P S F T R T W S G D K G P M A E T V S T Q V G T E G G L R A S H Q Q N G D A G G D A K V E L S P G P P K P A G R E V E P A P V G G E H P S A A A P G P G K H K K R R G A T R E R V V P P P K K R R T G V S F G D E H F A E T S Y Y F E G G L R K V R P Y Y F D F R T Y C K G R W V G H S L L H V F S T E F R A Q P L A Y Y E A A V R A G R L Q L N E K P V Q D L N I V L K D N D F L R N T V H R H E P P V T A E P I R L L A E N E D V V V V D K P S S I P V H P C G R F R H N T V I F I L G K E H Q L K E L H P L H R L D R L T S G V L M F A K T A A V S E R I H E Q V R D R Q L E K E Y V C R V E G E F P T E E V T C K E P I L V V S Y K V G V C R V D P R G K P C E T V F Q R L S Y N G Q S S V V R C R P L T G R T H Q I R V H L Q F L G H P I L N D P I Y N S V A W G P S R G R G G Y I P K T N E E L L R D L V A E H Q A K Q S L D V L D L C E G D L S P G L T D S T A P S S E L G K D D L E E L A A A A Q K M E E V A E A A P Q E L D T I A L A S E K A V E T D V M N Q E T D P L C A E C R L V R Q D P L P Q D L V M F L H A L R Y K G P G F E Y F S P M P A W A Q D D W Q K D

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q8IZ73-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q8IZ73-F1.cif  
DSSP Secondary Structures   Q8IZ73.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
Eukaryotic stand-alone pseudouridine synthases – RNA modifying enzymes and emerging regulators of gene expression? Anne C. Rintala-Dempsey and Ute Kothe [details] 28045575 10.1080/15476286.2016.1276150