ID Card:
Full name:
tRNA methyltransferase 9
Synonym:
fid
UniProt:
Q9VBJ3
Alpha Fold Predicted Structure:
AF-Q9VBJ3-F1
Enzyme type:
methyltransferase
Protein sequence:
MLSAELASSTALLNASYQRSNGPAKDEVCPSTIYDKCNTTTGAAAATMTKQLTTATATNAASSIGQPGDLAPTVISPTAPSTLTTGGAGGAGAGGTISPVSEATKTAPPPQPVEEKPSSSDASGRSAALERAYVHDVYEHCEEPTGPVRPRMAHFLSGLDPGSVVCDVGCGSGRYLTQCNPAICTIGVERCYRLSKVAHEKGGEVALCDNLELPFRDDSFDAVLSLAVVHHFATTERRVQALRELARILRIGGRVVITVWALEQRHRRFESQDVLIPWQPPKNRNYSYSDEEDDDNFQPPYHAYTEDSTNSSRSAGDGDSSSLSSSSPGESCYSFVRRAIQKLARGRRHAWFMDSWSSKDTKNDSSLDYEDAKDLPIELRRLEDFEDFPDPPLSAGLKSRSLGSILQPPPRQIVRSRSSVPSLGGPLIPGESKASAAALLLNNPESQQLQLQLQLNGRHSPTTTASAGNTLSRRPKLIKQKQSLCDDDAATPPAPESFQVVSSLNGSNGVVSSSLYTKSGCYAGNFHQHASATATPPSGDSGEGGVTGGPTGGPTFLRKQSSLNEDLMACNRLREKERVRKRIQKQTSLNEAFLCRSALFSKRLQVIREGFTTKIKSSTGSLERVTKTGISKLIQNIKSGPQAQTNPAQHPVQLDKNATLNNNNKQGVAATAHQHHHHHHHHPVHHLSHLILPASSTSAPVTYCSSVECTMSNLCHCSQYQQECPACADGGQGDKARRHSRESGSDSSKDSSLQSDTSIESEDSFASVIFIPKPEQHQQQLNYQQQHQNSNSSSSNSSSSNGQRAQGAAGRDQGVNPGSRLPPTHSVPTSPLIMPCPPTPAHSPAAIQGTVTSPPQSTSAVSAAMAILTPPSKPARFSFDEAHIKLQKEQHVDLQKELPKEKKEPLKVLPKEPLKESPPVRRITRQAIRDLPPIPKFRKQQSLQLQRQSFPIVRRASGSGVSTSASTTSLATKLLSLELFNPATDDLDSDSSEPSSPDSIDSVISAPRSAKVPSGSEEGEAASANSNSASQDEGEPSLAQLISLQQEQYHKGELQINSSRSHAEDDIILNADSAPLLPEKREAVQKQDCAEFAEQLSAQLQRELDDKTNRTECRYLDGIGMGDLSEILGGGKKRSNGDLSAFRDELRERRLMLANLSTQPSLQQSPVSSSTSSLSSQTRSFTIQEEDGEEEEEEENESSYSLGVYEHCKISKFNYKRNRHYQLNPETAYLLQDDGDSDVREDEDDVIPEEEEQEEQDEDAEAEALEARGGDQLGEGMSDYGQRRRNMAALKVQPPTTQQQQQQPQKEPNQAPNLQQRPSNDSLEHSNSSTNSLDSPSQGGASTHHRYYHVFREGELDALINHHVASLHIVSSYYERASWCVVAEKVQVWTI
Comments:
TRMT9B regulates synaptogenesis through a methyltransferase-dependent mechanism; TRMT9B might also function as a tRNA wobble uridine methyltransferase under specific conditions or methylate only one or a few, possibly brain-enriched tRNAs .
Alpha Fold Predicted Structure:
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Protein sequence:
M
L
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A
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Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
Expanded tRNA methyltransferase family member TRMT9B regulates synaptic growth and function
Caley A Hogan # 1, Scott J Gratz # 2, Jennifer L Dumouchel # 3, Rajan S Thakur 2, Ambar Delgado 2, Jenna M Lentini 4, Kimberly R Madhwani 5, Dragony Fu 4, Kate M O'Connor-Giles
[details]
37642556
10.15252/embr.202356808