ID Card:
Full name:
Small RNA 2'-O-methyltransferase
UniProt:
Q8CAE2
Alpha Fold Predicted Structure:
AF-Q8CAE2-F1
Protein sequence:
MEMAESIPCNSVVGGNFKEVSPEKVIRFKPPLYKQRYQFVRDLVDRHEPKKVADLGCGDAKLLKLLKIYPCIQLLVGVDINEEKLHSNGHRLSPYLGEFVKPRDLDLTVTLYHGSVVERDSRLLGFDLITCIELIEHLDSDDLARFPDVVFGYLSPAMVVISTPNAEFNPLFPTVTLRDADHKFEWSRMEFQTWALHVANCYNYRVEFTGVGTPPAGSEHVGYCTQIGVFTKNGGKLSKPSVSQQCDQHVYKPVYTTSYPSLQQEKVLKFVLVGELLIQVDRLRLRYQRMLRDREKDRGPKPGDMDSCPAPHLLLGAVFTEAEKARIESSPKPFCEGEKFYIPLQRLLTYPKLHRLCADEDRVRSLIADSVCLSSDGSAVVVDLHNSWDYRPEEN
Comments:
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.
Alpha Fold Predicted Structure:
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Protein sequence:
M
E
M
A
E
S
I
P
C
N
S
V
V
G
G
N
F
K
E
V
S
P
E
K
V
I
R
F
K
P
P
L
Y
K
Q
R
Y
Q
F
V
R
D
L
V
D
R
H
E
P
K
K
V
A
D
L
G
C
G
D
A
K
L
L
K
L
L
K
I
Y
P
C
I
Q
L
L
V
G
V
D
I
N
E
E
K
L
H
S
N
G
H
R
L
S
P
Y
L
G
E
F
V
K
P
R
D
L
D
L
T
V
T
L
Y
H
G
S
V
V
E
R
D
S
R
L
L
G
F
D
L
I
T
C
I
E
L
I
E
H
L
D
S
D
D
L
A
R
F
P
D
V
V
F
G
Y
L
S
P
A
M
V
V
I
S
T
P
N
A
E
F
N
P
L
F
P
T
V
T
L
R
D
A
D
H
K
F
E
W
S
R
M
E
F
Q
T
W
A
L
H
V
A
N
C
Y
N
Y
R
V
E
F
T
G
V
G
T
P
P
A
G
S
E
H
V
G
Y
C
T
Q
I
G
V
F
T
K
N
G
G
K
L
S
K
P
S
V
S
Q
Q
C
D
Q
H
V
Y
K
P
V
Y
T
T
S
Y
P
S
L
Q
Q
E
K
V
L
K
F
V
L
V
G
E
L
L
I
Q
V
D
R
L
R
L
R
Y
Q
R
M
L
R
D
R
E
K
D
R
G
P
K
P
G
D
M
D
S
C
P
A
P
H
L
L
L
G
A
V
F
T
E
A
E
K
A
R
I
E
S
S
P
K
P
F
C
E
G
E
K
F
Y
I
P
L
Q
R
L
L
T
Y
P
K
L
H
R
L
C
A
D
E
D
R
V
R
S
L
I
A
D
S
V
C
L
S
S
D
G
S
A
V
V
V
D
L
H
N
S
W
D
Y
R
P
E
E
N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
RNA methyltransferases in plants: Breakthroughs in function and evolution
Ricardo Ferraz 1, Sílvia Coimbra 2, Sandra Correia 3, Jorge Canhoto 4
[details]
36502609
10.1016/j.plaphy.2022.12.001