ID Card:
Full name:
N6-adenosine-methyltransferase MT-A70-like
UniProt:
O82486
Alpha Fold Predicted Structure:
AF-O82486-F1
Enzyme type:
methyltransferase
Protein sequence:
METESDDATITVVKDMRVRLENRIRTQHDAHLDLLSSLQSIVPDIVPSLDLSLKLISSFTNRPFVATPPLPEPKVEKKHHPIVKLGTQLQQLHGHDSKSMLVDSNQRDAEADGSSGSPMALVRAMVAECLLQRVPFSPTDSSTVLRKLENDQNARPAEKAALRDLGGECGPILAVETALKSMAEENGSVELEEFEVSGKPRIMVLAIDRTRLLKELPESFQGNNESNRVVETPNSIENATVSGGGFGVSGSGNFPRPEMWGGDPNMGFRPMMNAPRGMQMMGMHHPMGIMGRPPPFPLPLPLPVPSNQKLRSEEEDLKDVEALLSKKSFKEKQQSRTGEELLDLIHRPTAKEAATAAKFKSKGGSQVKYYCRYLTKEDCRLQSGSHIACNKRHFRRLIASHTDVSLGDCSFLDTCRHMKTCKYVHYELDMADAMMAGPDKALKPLRADYCSEAELGEAQWINCDIRSFRMDILGTFGVVMADPPWDIHMELPYGTMADDEMRTLNVPSLQTDGLIFLWVTGRAMELGRECLELWGYKRVEEIIWVKTNQLQRIIRTGRTGHWLNHSKEHCLVGIKGNPEVNRNIDTDVIVAEVRETSRKPDEMYAMLERIMPRARKLELFARMHNAHAGWLSLGNQLNGVRLINEGLRARFKASYPEIDVQPPSPPRASAMETDNEPMAIDSITA
Comments:
Catalytic subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs.
Associates with MTB, FIP37, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences.
N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing.
Alpha Fold Predicted Structure:
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Protein sequence:
M
E
T
E
S
D
D
A
T
I
T
V
V
K
D
M
R
V
R
L
E
N
R
I
R
T
Q
H
D
A
H
L
D
L
L
S
S
L
Q
S
I
V
P
D
I
V
P
S
L
D
L
S
L
K
L
I
S
S
F
T
N
R
P
F
V
A
T
P
P
L
P
E
P
K
V
E
K
K
H
H
P
I
V
K
L
G
T
Q
L
Q
Q
L
H
G
H
D
S
K
S
M
L
V
D
S
N
Q
R
D
A
E
A
D
G
S
S
G
S
P
M
A
L
V
R
A
M
V
A
E
C
L
L
Q
R
V
P
F
S
P
T
D
S
S
T
V
L
R
K
L
E
N
D
Q
N
A
R
P
A
E
K
A
A
L
R
D
L
G
G
E
C
G
P
I
L
A
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T
A
L
K
S
M
A
E
E
N
G
S
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L
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F
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G
K
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M
V
L
A
I
D
R
T
R
L
L
K
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L
P
E
S
F
Q
G
N
N
E
S
N
R
V
V
E
T
P
N
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I
E
N
A
T
V
S
G
G
G
F
G
V
S
G
S
G
N
F
P
R
P
E
M
W
G
G
D
P
N
M
G
F
R
P
M
M
N
A
P
R
G
M
Q
M
M
G
M
H
H
P
M
G
I
M
G
R
P
P
P
F
P
L
P
L
P
L
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V
P
S
N
Q
K
L
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S
E
E
E
D
L
K
D
V
E
A
L
L
S
K
K
S
F
K
E
K
Q
Q
S
R
T
G
E
E
L
L
D
L
I
H
R
P
T
A
K
E
A
A
T
A
A
K
F
K
S
K
G
G
S
Q
V
K
Y
Y
C
R
Y
L
T
K
E
D
C
R
L
Q
S
G
S
H
I
A
C
N
K
R
H
F
R
R
L
I
A
S
H
T
D
V
S
L
G
D
C
S
F
L
D
T
C
R
H
M
K
T
C
K
Y
V
H
Y
E
L
D
M
A
D
A
M
M
A
G
P
D
K
A
L
K
P
L
R
A
D
Y
C
S
E
A
E
L
G
E
A
Q
W
I
N
C
D
I
R
S
F
R
M
D
I
L
G
T
F
G
V
V
M
A
D
P
P
W
D
I
H
M
E
L
P
Y
G
T
M
A
D
D
E
M
R
T
L
N
V
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S
L
Q
T
D
G
L
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L
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T
G
R
A
M
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L
G
R
E
C
L
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L
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G
Y
K
R
V
E
E
I
I
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V
K
T
N
Q
L
Q
R
I
I
R
T
G
R
T
G
H
W
L
N
H
S
K
E
H
C
L
V
G
I
K
G
N
P
E
V
N
R
N
I
D
T
D
V
I
V
A
E
V
R
E
T
S
R
K
P
D
E
M
Y
A
M
L
E
R
I
M
P
R
A
R
K
L
E
L
F
A
R
M
H
N
A
H
A
G
W
L
S
L
G
N
Q
L
N
G
V
R
L
I
N
E
G
L
R
A
R
F
K
A
S
Y
P
E
I
D
V
Q
P
P
S
P
P
R
A
S
A
M
E
T
D
N
E
P
M
A
I
D
S
I
T
A
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
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