General Data

RNA Type	mRNA
Original Source	Sci-ModoM
Transcript ID:	ENST00000539760
Gene ID:	ENSG00000165819
Gene Name:	METTL3
Sequence (UNICHARACTER ENCODING)	AGUGCCUACUGCACCCACCUCUGGUGGCCCUAAGCCCAGCACAGCUUCAGCAGUUCCUGAAUUAGCUACAGAUCCUGAGUUAGAGAAGAAGUUGCUACACCACCUCUCUGAUCUGGCCUUAЖCAUUGCCCACUGAUGCUGUGUCCAUCUGUCUUGCCAUCUCCACGCCAGAUGCUCCUGCCACUCAAGAUGGGGUAGAAAGCCUCCUGCAGAAGUUUGCAGCUCAGGAGUUGAUUGAGGUAAAGCGAGGUCUCCUACAAGAUGAUGCACAPCCUACUCUUGUAACCUAUGCUGACCAUUCCAAGCUCUCUGCCAUGAUGGGUGCUGUGGCAGAAAAGAAGGGCCCUGGGGAGGUAGCAGGGЖCUGUCACAGGGCAGAAGCGGCGUGCAGAACAGGЖCUCGACUACAGUAGCUGCCUUUGCCAGUUCGUUAGUCUCUGGUCUGAACUCUUCAGCAUCGGAACCAGCAAAGGAGCCAGCCAAGAAAUCAAGGAAACAUGCUGCCUCAGAUGUUGAUCUGGAGAUAGAGAGCCUUCUGAЖCCAACAGUCCACUAAGGAACAACAGAGCAAGAAGGUCAGUCAGGAGAUCCUAGAGCUAUUAAAUACUACAACAGCCAAGGAACAAUCCAUUGUUGAAAAAUUUCGCUCUCGAGGUCGGGCCCAAGUGCAAGAAUUCUGUGACUAUGGAЖCCAAGGAGGAGUGCAUGAAAGCCAGUGAUGCUGAUCGACCCUGUCGCAAGCUGCACUUCAGACGAAUUAUCAAUAAACACACUGAUGAGUCUPUAGGUGACUGCUCUUUCCUUAAUACAUGUUUCCACAUGGAUACCUGCAAGUAUGUUCACUAUGAAAUUGAUGCUUGCAUGGAUUCUGAGGCCCCUGGCAGCAAAGACCACACGCCAAGCCAGGAGCUUGCUCUUACACAGAGUGUCGGAGGUGAUUCCAGUGCAGACCGACUCUUCCCACCUCAGGGCCAUGGAGUUGGGGAGAGAAUGUCUAAACCUCUGGGGGUAUGAACGGGUAGAUGAAAUUAUUUGGGUGAAGACAAAUCAACUGCAACGCAUCAUUCGGACAGGCCGUACAGGUCACUGGUUGAЖCCAUGGGAAGGAACACUGCUUGGUUCGUUCCACCAGUCAUAAACCAGAUGAAAUCUAUGGCAUGAUUGAAAGACUAUCUCCUGGCACUCGCAAGAUUGAGUUAUUUGGACGACCACACAAUGUGCAACCCAACUGGAUCACCCUUGGAAACCAACUGGAUGGGAUCCACCUACUAGЖCCCAGAUGUGGUUGCACGGUUCAAGCAAAGGUACCCAGAUGGUAUCAUCUCUAAACCUAAGAAUUUAUAGAAGCACUUCCUUACAGAGCUAAGAAUCCAUAGCCAUGGCUCUGUAAGCUAAACCUGAAGAGUGAUAUUUGUACAAUAGCUUUCUUCUUUAUUUAAAUAAACAUUUGUAUUGUAGUUGGGAUUCUG
Sequence (SHORT NAMES ENCODING)	AGUGCCUACUGCACCCACCUCUGGUGGCCCUAAGCCCAGCACAGCUUCAGCAGUUCCUGAAUUAGCUACAGAUCCUGAGUUAGAGAAGAAGUUGCUACACCACCUCUCUGAUCUGGCCUUAm6ACAUUGCCCACUGAUGCUGUGUCCAUCUGUCUUGCCAUCUCCACGCCAGAUGCUCCUGCCACUCAAGAUGGGGUAGAAAGCCUCCUGCAGAAGUUUGCAGCUCAGGAGUUGAUUGAGGUAAAGCGAGGUCUCCUACAAGAUGAUGCACAYCCUACUCUUGUAACCUAUGCUGACCAUUCCAAGCUCUCUGCCAUGAUGGGUGCUGUGGCAGAAAAGAAGGGCCCUGGGGAGGUAGCAGGGm6ACUGUCACAGGGCAGAAGCGGCGUGCAGAACAGGm6ACUCGACUACAGUAGCUGCCUUUGCCAGUUCGUUAGUCUCUGGUCUGAACUCUUCAGCAUCGGAACCAGCAAAGGAGCCAGCCAAGAAAUCAAGGAAACAUGCUGCCUCAGAUGUUGAUCUGGAGAUAGAGAGCCUUCUGAm6ACCAACAGUCCACUAAGGAACAACAGAGCAAGAAGGUCAGUCAGGAGAUCCUAGAGCUAUUAAAUACUACAACAGCCAAGGAACAAUCCAUUGUUGAAAAAUUUCGCUCUCGAGGUCGGGCCCAAGUGCAAGAAUUCUGUGACUAUGGAm6ACCAAGGAGGAGUGCAUGAAAGCCAGUGAUGCUGAUCGACCCUGUCGCAAGCUGCACUUCAGACGAAUUAUCAAUAAACACACUGAUGAGUCUYUAGGUGACUGCUCUUUCCUUAAUACAUGUUUCCACAUGGAUACCUGCAAGUAUGUUCACUAUGAAAUUGAUGCUUGCAUGGAUUCUGAGGCCCCUGGCAGCAAAGACCACACGCCAAGCCAGGAGCUUGCUCUUACACAGAGUGUCGGAGGUGAUUCCAGUGCAGACCGACUCUUCCCACCUCAGGGCCAUGGAGUUGGGGAGAGAAUGUCUAAACCUCUGGGGGUAUGAACGGGUAGAUGAAAUUAUUUGGGUGAAGACAAAUCAACUGCAACGCAUCAUUCGGACAGGCCGUACAGGUCACUGGUUGAm6ACCAUGGGAAGGAACACUGCUUGGUUCGUUCCACCAGUCAUAAACCAGAUGAAAUCUAUGGCAUGAUUGAAAGACUAUCUCCUGGCACUCGCAAGAUUGAGUUAUUUGGACGACCACACAAUGUGCAACCCAACUGGAUCACCCUUGGAAACCAACUGGAUGGGAUCCACCUACUAGm6ACCCAGAUGUGGUUGCACGGUUCAAGCAAAGGUACCCAGAUGGUAUCAUCUCUAAACCUAAGAAUUUAUAGAAGCACUUCCUUACAGAGCUAAGAAUCCAUAGCCAUGGCUCUGUAAGCUAAACCUGAAGAGUGAUAUUUGUACAAUAGCUUUCUUCUUUAUUUAAAUAAACAUUUGUAUUGUAGUUGGGAUUCUG
Sequence (MODOMICS CODE ENCODING)	AGUGCCUACUGCACCCACCUCUGGUGGCCCUAAGCCCAGCACAGCUUCAGCAGUUCCUGAAUUAGCUACAGAUCCUGAGUUAGAGAAGAAGUUGCUACACCACCUCUCUGAUCUGGCCUUA2000000006ACAUUGCCCACUGAUGCUGUGUCCAUCUGUCUUGCCAUCUCCACGCCAGAUGCUCCUGCCACUCAAGAUGGGGUAGAAAGCCUCCUGCAGAAGUUUGCAGCUCAGGAGUUGAUUGAGGUAAAGCGAGGUCUCCUACAAGAUGAUGCACA2000000009UCCUACUCUUGUAACCUAUGCUGACCAUUCCAAGCUCUCUGCCAUGAUGGGUGCUGUGGCAGAAAAGAAGGGCCCUGGGGAGGUAGCAGGG2000000006ACUGUCACAGGGCAGAAGCGGCGUGCAGAACAGG2000000006ACUCGACUACAGUAGCUGCCUUUGCCAGUUCGUUAGUCUCUGGUCUGAACUCUUCAGCAUCGGAACCAGCAAAGGAGCCAGCCAAGAAAUCAAGGAAACAUGCUGCCUCAGAUGUUGAUCUGGAGAUAGAGAGCCUUCUGA2000000006ACCAACAGUCCACUAAGGAACAACAGAGCAAGAAGGUCAGUCAGGAGAUCCUAGAGCUAUUAAAUACUACAACAGCCAAGGAACAAUCCAUUGUUGAAAAAUUUCGCUCUCGAGGUCGGGCCCAAGUGCAAGAAUUCUGUGACUAUGGA2000000006ACCAAGGAGGAGUGCAUGAAAGCCAGUGAUGCUGAUCGACCCUGUCGCAAGCUGCACUUCAGACGAAUUAUCAAUAAACACACUGAUGAGUCU2000000009UUAGGUGACUGCUCUUUCCUUAAUACAUGUUUCCACAUGGAUACCUGCAAGUAUGUUCACUAUGAAAUUGAUGCUUGCAUGGAUUCUGAGGCCCCUGGCAGCAAAGACCACACGCCAAGCCAGGAGCUUGCUCUUACACAGAGUGUCGGAGGUGAUUCCAGUGCAGACCGACUCUUCCCACCUCAGGGCCAUGGAGUUGGGGAGAGAAUGUCUAAACCUCUGGGGGUAUGAACGGGUAGAUGAAAUUAUUUGGGUGAAGACAAAUCAACUGCAACGCAUCAUUCGGACAGGCCGUACAGGUCACUGGUUGA2000000006ACCAUGGGAAGGAACACUGCUUGGUUCGUUCCACCAGUCAUAAACCAGAUGAAAUCUAUGGCAUGAUUGAAAGACUAUCUCCUGGCACUCGCAAGAUUGAGUUAUUUGGACGACCACACAAUGUGCAACCCAACUGGAUCACCCUUGGAAACCAACUGGAUGGGAUCCACCUACUAG2000000006ACCCAGAUGUGGUUGCACGGUUCAAGCAAAGGUACCCAGAUGGUAUCAUCUCUAAACCUAAGAAUUUAUAGAAGCACUUCCUUACAGAGCUAAGAAUCCAUAGCCAUGGCUCUGUAAGCUAAACCUGAAGAGUGAUAUUUGUACAAUAGCUUUCUUCUUUAUUUAAAUAAACAUUUGUAUUGUAGUUGGGAUUCUG

Score Table

_{Table containing the score explanation. Score identify the level of experimental reliability and evidence so as exaplained in the 2023 release manuscript. Class 1 should be considered as highlyrelevant. Class 2 evidences are considered as Solid, namely large errors are unlikely and minor errors should not undermine the meaning of data. Class 3 is considered as speculative and errors are expected. Class 4 is considered as questionable. Class 5 evidence means that verification and data are still to be collected. Class 6 data cannot be estimated.}

Method Classification	Score
Multiple direct experimental evidence	1
Direct experimental evidence	2
Inferred based on indirect experimental evidence	3
Predicted computationally	4
Evidence not yet annotated (Unknown)	5
Irrelevant	6

Modification Positions

_{Table containing the original modifications present in the MODOMICS sequences. Edit locations not originally present in the RNA sequences are marked by their source. Their scores are in third row.}

Position in the Sequence	122	271	362	396	537	686	779	1090	1267
Modification Positions	m6A	Y	m6A	m6A	m6A	m6A	Y	m6A	m6A
Genomic Coordinates	14:21503708:-	14:21503473:-	14:21503382:-	14:21503348:-	14:21503207:-	14:21501789:-	14:21501098:-	14:21499514:-	14:21498328:-
Level of Experimental Evidence	3	3	3	3	3	3	3	3	3
Level of Experimental Reliability	3	3	3	3	3	3	3	3	3
Source	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM
EUFIDs	BtsJQJ3DteUq bXBqJigD9oV3 dknfVe6BK8aP f6YSioLdAWpr XWZVGdLC6gGJ iezFbUdmY3A6 S9vNeQQYrhac Yfn77uLS5tv8	BtsJQJ3DteUq bXBqJigD9oV3 dknfVe6BK8aP f6YSioLdAWpr XWZVGdLC6gGJ iezFbUdmY3A6 S9vNeQQYrhac Yfn77uLS5tv8	6UuHp6YApVKv gBgcfFQ5WN9C gZuvgwMuBfgh jNkxUQNx8GRd Mg9GixDBFQAT msuJfBpJvM5H QpiKdbVikVz2 UN3tNpbCPHYf VL7zkHvkfkoB VyCX26p5UBRL WdHxkJGRmFxn aJksAshEgQ8U Lny8GcCeVGc9 834aFpha8RvT dA7YoLwHrzgR ZuM5xpZmNuDL BtsJQJ3DteUq bXBqJigD9oV3 dknfVe6BK8aP f6YSioLdAWpr XWZVGdLC6gGJ iezFbUdmY3A6 S9vNeQQYrhac Yfn77uLS5tv8	3TeAZFYFxgvp 4HMi5ykupT9V 5aTkEfEpX8Xm 6UuHp6YApVKv aivdrAsbdKEU gZuvgwMuBfgh jNkxUQNx8GRd msuJfBpJvM5H NjZ8bGGJsNSR Q36pf44ZRvxu QmcpiJ88DBDn QpiKdbVikVz2 UN3tNpbCPHYf VL7zkHvkfkoB VyCX26p5UBRL WdHxkJGRmFxn Lny8GcCeVGc9 BtsJQJ3DteUq bXBqJigD9oV3 dknfVe6BK8aP f6YSioLdAWpr XWZVGdLC6gGJ iezFbUdmY3A6 S9vNeQQYrhac Yfn77uLS5tv8	BtsJQJ3DteUq bXBqJigD9oV3 dknfVe6BK8aP f6YSioLdAWpr XWZVGdLC6gGJ iezFbUdmY3A6 S9vNeQQYrhac Yfn77uLS5tv8	BtsJQJ3DteUq bXBqJigD9oV3 dknfVe6BK8aP f6YSioLdAWpr XWZVGdLC6gGJ iezFbUdmY3A6 S9vNeQQYrhac Yfn77uLS5tv8	BtsJQJ3DteUq bXBqJigD9oV3 dknfVe6BK8aP f6YSioLdAWpr oZ9Kp5NX8Hv5 XWZVGdLC6gGJ iezFbUdmY3A6 S9vNeQQYrhac Yfn77uLS5tv8	3TeAZFYFxgvp 4HMi5ykupT9V 5aTkEfEpX8Xm 6UuHp6YApVKv aivdrAsbdKEU gZuvgwMuBfgh jNkxUQNx8GRd msuJfBpJvM5H NjZ8bGGJsNSR Q36pf44ZRvxu QmcpiJ88DBDn QpiKdbVikVz2 UN3tNpbCPHYf V5PvfiKsgFMd VL7zkHvkfkoB VyCX26p5UBRL WdHxkJGRmFxn BtsJQJ3DteUq bXBqJigD9oV3 dknfVe6BK8aP f6YSioLdAWpr oZ9Kp5NX8Hv5 XWZVGdLC6gGJ iezFbUdmY3A6 S9vNeQQYrhac Yfn77uLS5tv8	BtsJQJ3DteUq bXBqJigD9oV3 dknfVe6BK8aP f6YSioLdAWpr Mk6ShCGm6RBJ oZ9Kp5NX8Hv5 XWZVGdLC6gGJ iezFbUdmY3A6 S9vNeQQYrhac a7o5Kmjr4Tdp Yfn77uLS5tv8