DNAmoreDB - A Database of Deoxyribozymes

DNAzyme description

 Reaction  Reacting groups  Substrates Product  Metal ion Linkage  Seq description
RNA cleavage Group 1 - 2'-OH of rA

Group 2 - vicinal phosphate

S: cleavage in cis
specific cleavage at desired position Tm3+
RNA phosphodiester N 35
 Buffer conditions
50 mM MES pH 6.0, 25 mM NaCl, 10 µM Tm3+
 Catalytic region of the DNAzyme
CTGCAGAATTCTAATACGAGTCACTATAGGAAGATGGCGAAACATCTTCTATGTTACTATCTAACGAGAAGAGAACCATAACTAGCGGTAAGCTTG

 Reported in...

Year of Publication First Author Laboratory Title PubMed ID DOI Reaction
2015 P-J J Huang J Liu A new heavy lanthanide-dependent DNAzyme displaying strong metal cooperativity and unrescuable phosphorothioate effect. 25488814 10.1093/nar/gku1296 RNA cleavage

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