Year of pub. First Author Laboratory Title PubMed ID DOI Reaction
2005 Y Wang S K Silverman Efficient one-step synthesis of biologically related lariat RNAs by a deoxyribozyme. 16086354 10.1002/anie.200501643 RNA ligation
2003 Y Wang S K Silverman Characterization of deoxyribozymes that synthesize branched RNA. 14690435 10.1021/bi0355847 RNA ligation
2008 T P Mui S K Silverman Convergent and general one-step DNA-catalyzed synthesis of multiply branched DNA. 18808125 10.1021/ol801568q DNA ligation
2004 D J-F Chinnapen D Sen A deoxyribozyme that harnesses light to repair thymine dimers in DNA. 14691255 10.1073/pnas.0305943101 Thymine dimer repair
2010 F Wachowius C Höbartner Combinatorial mutation interference analysis reveals functional nucleotides required for DNA catalysis. 20872387 10.1002/anie.201003940 RNA ligation
1994 R R Breaker G F Joyce A DNA enzyme that cleaves RNA. 9383394 10.1016/1074-5521(94)90014-0 RNA cleavage
1997 S W Santoro G F Joyce A general purpose RNA-cleaving DNA enzyme. 9113977 10.1073/pnas.94.9.4262 RNA cleavage
1997 C R Geyer D Sen Evidence for the metal-cofactor independence of an RNA phosphodiester-cleaving DNA enzyme. 9281526 10.1016/s1074-5521(97)90244-1 RNA cleavage
1996 Y Li D Sen A catalytic DNA for porphyrin metallation None 10.1038/nsb0996-743 Porphyrin metalation
2007 C Höbartner S K Silverman Site-selective depurination by a periodate-dependent deoxyribozyme. 17534508 10.1039/b704507g DNA depurination
2008 P I Pradeepkumar Scott K Silverman DNA-catalyzed formation of nucleopeptide linkages. 18214866 10.1002/anie.200703676 Covalent Modification of Amino Acid Side Chains
RNA ligation
2008 D M Kost S K Silverman Controlling the direction of site-selectivity and regioselectivity in RNA ligation by Zn2+-dependent deoxyribozymes that use 2',3'-cyclic phosphate RNA substrates. 19005599 10.1039/B813566E RNA ligation
2000 A Peracchi Preferential Activation of the 8–17 Deoxyribozyme by Ca2+ Ions EVIDENCE FOR THE IDENTITY OF 8–17 WITH THE CATALYTIC DOMAIN OF THE MG5 DEOXYRIBOZYME None 10.1074/jbc.275.16.11693 RNA cleavage
1996 D Faulhammer M Famulok The Ca2+ Ion as a Cofactor for a Novel RNA‐Cleaving Deoxyribozyme None 10.1002/anie.199628371 RNA cleavage
2005 Y Wang S K Silverman Directing the outcome of deoxyribozyme selections to favor native 3'-5' RNA ligation. 15723545 10.1021/bi0478291 RNA ligation
2006 N Paul G F Joyce Conversion of a ribozyme to a deoxyribozyme through in vitro evolution. 16638538 10.1016/j.chembiol.2006.01.007 RNA ligation
2003 Y Wang S K Silverman Deoxyribozymes that synthesize branched and lariat RNA. 12783536 10.1021/ja035150z RNA ligation
2004 T K Prior S K Silverman Structure-function correlations derived from faster variants of a RNA ligase deoxyribozyme. 14960718 10.1093/nar/gkh263 RNA ligation
2004 R L Coppins S K Silverman A DNA enzyme that mimics the first step of RNA splicing. 14758353 10.1038/nsmb727 RNA ligation
2011 F Wachowius C Höbartner Probing essential nucleobase functional groups in aptamers and deoxyribozymes by nucleotide analogue interference mapping of DNA. 21863810 10.1021/ja205894w RNA ligation
2005 W E Purtha S K Silverman General deoxyribozyme-catalyzed synthesis of native 3'-5' RNA linkages. 16173722 10.1021/ja0533702 RNA ligation
2005 K A Hoadley S K Silverman Zn2+-dependent deoxyribozymes that form natural and unnatural RNA linkages. 15966746 10.1021/bi050146g RNA ligation
2007 C Höbartner S K Silverman Engineering a selective small-molecule substrate binding site into a deoxyribozyme. 17694519 10.1002/anie.200702217 RNA ligation
2005 R L Coppins S K Silverman Mimicking the first step of RNA splicing: an artificial DNA enzyme can synthesize branched RNA using an oligonucleotide leaving group as a 5'-exon analogue. 16216067 10.1021/bi0507229 RNA ligation
2005 R L Coppins S K Silverman A deoxyribozyme that forms a three-helix-junction complex with its RNA substrates and has general RNA branch-forming activity. 15740125 10.1021/ja044881b RNA ligation
2004 R L Coppins S K Silverman Rational modification of a selection strategy leads to deoxyribozymes that create native 3'-5' RNA linkages. 15600344 10.1021/ja045817x RNA ligation
2006 E Zelin Scott K Silverman Adenosine is inherently favored as the branch-site RNA nucleotide in a structural context that resembles natural RNA splicing. 16503631 10.1021/bi052499l RNA ligation
2005 D R Semlow S K Silverman Parallel selections in vitro reveal a preference for 2'-5' RNA ligation upon deoxyribozyme-mediated opening of a 2',3'-cyclic phosphate. 16007488 10.1007/s00239-004-0326-y RNA ligation
2018 A Barlev D Sen DNA's Encounter with Ultraviolet Light: An Instinct for Self-Preservation? 29419284 10.1021/acs.accounts.7b00582 Thymine dimer repair
2016 A Barlev D Sen DNA Repair by DNA: The UV1C DNAzyme Catalyzes Photoreactivation of Cyclobutane Thymine Dimers in DNA More Effectively than Their de Novo Formation. 27726378 10.1021/acs.biochem.6b00951 Thymine dimer repair
1995 R R Breaker G F Joyce A DNA enzyme with Mg(2+)-dependent RNA phosphoesterase activity. 9383471 10.1016/1074-5521(95)90028-4 RNA cleavage
1997 D Faulhammer M Famulok Characterization and divalent metal-ion dependence of in vitro selected deoxyribozymes which cleave DNA/RNA chimeric oligonucleotides. 9191064 10.1006/jmbi.1997.1036 RNA cleavage
1998 A Roth R R Breaker An amino acid as a cofactor for a catalytic polynucleotide. 9600911 10.1073/pnas.95.11.6027 RNA cleavage
2008 M Hollenstein D M Perrin A Highly Selective DNAzyme Sensor for Mercuric Ions None 10.1002/anie.200800960 RNA cleavage
2000 J Nowakowski G F Joyce Alternative conformations of a nucleic acid four-way junction. 10864501 10.1006/jmbi.2000.3826 RNA cleavage
1995 B Cuenoud J W Szostak A DNA metalloenzyme with DNA ligase activity. 7791880 10.1038/375611a0 DNA ligation
2012 T E Velez S K Silverman Systematic evaluation of the dependence of deoxyribozyme catalysis on random region length. 23088677 10.1021/co300111f DNA cleavage
Covalent Modification of Amino Acid Side Chains
2018 M V Sednev C Höbartner N -Methyladenosine-Sensitive RNA-Cleaving Deoxyribozymes. 30276938 10.1002/anie.201808745 RNA cleavage
2003 A Flynn-Charlebois S K Silverman In vitro evolution of an RNA-cleaving DNA enzyme into an RNA ligase switches the selectivity from 3'-5' to 2'-5'. 12720447 10.1021/ja0340331 RNA ligation
2019 J Aranda M Orozco An artificial DNAzyme RNA ligase shows a reaction mechanism resembling that of cellular polymerases None 10.1038/s41929-019-0290-y RNA ligation
1997 Y Li D Sen Toward an efficient DNAzyme. 9154943 10.1021/bi962694n Porphyrin metalation
2013 J Chandrasekar S K Silverman Catalytic DNA with phosphatase activity. 23509279 10.1073/pnas.1221946110 Dephosphorylation
2005 E D Pratico S K Silverman A deoxyribozyme that synthesizes 2',5'-branched RNA with any branch-site nucleotide. 15967808 10.1093/nar/gki656 RNA ligation
2000 J Li Y Lu A Highly Sensitive and Selective Catalytic DNA Biosensor for Lead Ions None 10.1021/ja0021316 RNA cleavage
1999 J Nowakowski G F Joyce Crystal structure of an 82-nucleotide RNA–DNA complex formed by the 10-23 DNA enzyme None 10.1038/5839 RNA cleavage
2000 Y Li R R Breaker Capping DNA with DNA. 10715132 10.1021/bi992710r DNA capping
2017 H Liu J Gan Crystal structure of an RNA-cleaving DNAzyme. 29222499 10.1038/s41467-017-02203-x RNA cleavage
2003 B L Ricca S K Silverman Optimization and generality of a small deoxyribozyme that ligates RNA. 12860124 10.1016/S0022-2836(03)00654-5 RNA ligation
2009 R E Thorne D Sen A deoxyribozyme, Sero1C, uses light and serotonin to repair diverse pyrimidine dimers in DNA. 19281822 10.1016/j.jmb.2009.02.064 Thymine dimer repair
2003 A Flynn-Charlebois S K Silverman Deoxyribozymes with 2'-5' RNA ligase activity. 12603132 10.1021/ja028774y RNA ligation
2016 A Ponce-Salvatierra V Pena Crystal structure of a DNA catalyst. 26735012 10.1038/nature16471 RNA ligation
2011 Y Xiao S K Silverman Merely two mutations switch a DNA-hydrolyzing deoxyribozyme from heterobimetallic (Zn2+/Mn2+) to monometallic (Zn2+-only) behavior. 21125108 10.1039/c0cc04575f DNA cleavage
2002 W Wang Y Li Sequence diversity, metal specificity, and catalytic proficiency of metal-dependent phosphorylating DNA enzymes. 11983339 10.1016/S1074-5521(02)00127-8 DNA phosphorylation
2000 J Li Y Lu In vitro selection and characterization of a highly efficient Zn(II)-dependent RNA-cleaving deoxyribozyme. 10606646 10.1093/nar/28.2.481 RNA cleavage
2011 O Y Wong S K Silverman DNA-catalyzed covalent modification of amino acid side chains in tethered and free peptide substrates. 21510668 10.1021/bi200585n Covalent Modification of Amino Acid Side Chains
2016 R Saran J Liu A Silver DNAzyme. 26977895 10.1021/acs.analchem.6b00327 RNA cleavage
2013 S M Walsh S K Silverman DNA catalysts with tyrosine kinase activity. 24066831 10.1021/ja407586u Tyrosine Phosphorylation
2011 C S Lee S K Silverman Improved deoxyribozymes for synthesis of covalently branched DNA and RNA. 20739352 10.1093/nar/gkq753 RNA ligation
DNA ligation
2009 G S Sekhon D Sen Unusual DNA-DNA cross-links between a photolyase deoxyribozyme, UV1C, and its bound oligonucleotide substrate. 19514779 10.1021/bi900531z Thymine dimer repair
2007 D J-F Chinnapen D Sen Towards elucidation of the mechanism of UV1C, a deoxyribozyme with photolyase activity. 17141270 10.1016/j.jmb.2006.10.062 Thymine dimer repair
1996 N Carmi R R Breaker In vitro selection of self-cleaving DNAs. 9000012 10.1016/s1074-5521(96)90170-2 DNA cleavage
2000 T L Sheppard G F Joyce A DNA enzyme with N-glycosylase activity. 10884411 10.1073/pnas.97.14.7802 DNA depurination
2011 O Y Wong S K Silverman DNA-catalyzed reductive amination. 21994131 10.1002/anie.201104976 Reductive amination
2016 P Wang S K Silverman DNA-Catalyzed Introduction of Azide at Tyrosine for Peptide Modification. 27391404 10.1002/anie.201604364 Tyrosine azido‐adenylylation
2014 C Chu S K Silverman A generalizable DNA-catalyzed approach to peptide-nucleic acid conjugation. 25056930 10.1002/cbic.201402255 Covalent Modification of Amino Acid Side Chains
2010 A Sachdeva S K Silverman DNA-catalyzed serine side chain reactivity and selectivity. 20234910 10.1039/b927317d Covalent Modification of Amino Acid Side Chains
2012 A Sachdeva S K Silverman Covalent tagging of phosphorylated peptides by phosphate-specific deoxyribozymes. 22315198 10.1002/cbic.201200048 Covalent Modification of Phosphorylated Amino Acid Side Chains
2016 A J Camden S K Silverman DNA Oligonucleotide 3'-Phosphorylation by a DNA Enzyme. 27063020 10.1021/acs.biochem.6b00151 DNA phosphorylation
2014 V Dokukin S K Silverman A modular tyrosine kinase deoxyribozyme with discrete aptamer and catalyst domains. 25000337 10.1039/c4cc04253k Tyrosine Phosphorylation
2017 Y Lee S K Silverman DNA-Catalyzed DNA Cleavage by a Radical Pathway with Well-Defined Products. 27935689 10.1021/jacs.6b10274 DNA cleavage
2012 A Sachdeva S K Silverman DNA-catalyzed reactivity of a phosphoramidate functional group and formation of an unusual pyrophosphoramidate linkage. 22042295 10.1039/c1ob06088k Covalent Modification of Amino Acid Side Chains
2008 M Chandra S K Silverman DNA and RNA can be equally efficient catalysts for carbon-carbon bond formation. 18271591 10.1021/ja7111965 Diels-Alder
2013 D J Parker S K Silverman DNA catalysis of a normally disfavored RNA hydrolysis reaction. 23697866 10.1021/ja4032488 RNA cleavage
2014 B M Brandsen S K Silverman DNA-catalyzed lysine side chain modification. 24981820 10.1002/anie.201404622 Covalent Modification of Amino Acid Side Chains
2015 J Chandrasekar S K Silverman Phosphoserine Lyase Deoxyribozymes: DNA-Catalyzed Formation of Dehydroalanine Residues in Peptides. 26200899 10.1021/jacs.5b06308 Covalent Modification of Phosphorylated Amino Acid Side Chains
2016 C Chu S K Silverman Assessing histidine tags for recruiting deoxyribozymes to catalyze peptide and protein modification reactions. 27138704 10.1039/c6ob00716c Tyrosine Phosphorylation
Covalent Modification of Amino Acid Side Chains
2015 S M Walsh S K Silverman Identification of Sequence-Selective Tyrosine Kinase Deoxyribozymes. 26407964 10.1007/s00239-015-9699-3 Tyrosine Phosphorylation
2016 C Zhou S K Silverman DNA-Catalyzed Amide Hydrolysis. 26854515 10.1021/jacs.5b12647 Amide hydrolysis
2016 A R Hesser S K Silverman DNA-catalyzed glycosylation using aryl glycoside donors. 27355482 10.1039/c6cc04329a Glycosylation
2016 A Kasprowicz J Ciesiołka Characterization of Highly Efficient RNA‐Cleaving DNAzymes that Function at Acidic pH with No Divalent Metal‐Ion Cofactors None 10.1002/open.201600141 RNA cleavage
2019 D Peng J Liu Efficient DNA-Catalyzed Porphyrin Metalation for Fluorescent Ratiometric Pb Detection. 31414597 10.1021/acs.analchem.9b02759 Porphyrin metalation
2020 H Yang J Liu Pb2+ as a Substrate and a Cofactor of a Porphyrin Metalation DNAzyme. 32202058 10.1002/cbic.202000073 Porphyrin metalation
2013 J Yang M T Bowser Capillary electrophoresis-SELEX selection of catalytic DNA aptamers for a small-molecule porphyrin target. 23234289 10.1021/ac302721j Porphyrin metalation
1998 N Carmi R R Breaker Cleaving DNA with DNA. 9482868 10.1073/pnas.95.5.2233 DNA cleavage
2020 A Liaqat C Höbartner N 6-isopentenyladenosine in RNA determines the cleavage site of endonuclease deoxyribozymes. 32681686 10.1002/anie.202006218 RNA cleavage
2020 K Liu D Sen CLICK-17, a DNA enzyme that harnesses ultra-low concentrations of either Cu+ or Cu2+ to catalyze the azide-alkyne 'click' reaction in water. 32520335 10.1093/nar/gkaa502 Copper-mediated Azide-Alkyne Cycloaddition (CuAAC)
2013 B M Brandsen S K Silverman DNA-catalyzed hydrolysis of esters and aromatic amides. 24127695 10.1021/ja4077233 Ester hydrolysis
Amide hydrolysis
2009 M Chandra S K Silverman DNA-catalyzed sequence-specific hydrolysis of DNA None 10.1038/nchembio.201 DNA cleavage
2012 Y Xiao S K Silverman Establishing broad generality of DNA catalysts for site-specific hydrolysis of single-stranded DNA. 22021383 10.1093/nar/gkr860 DNA cleavage
2010 Y Xiao S K Silverman Functional compromises among pH tolerance, site specificity, and sequence tolerance for a DNA-hydrolyzing deoxyribozyme. 20923239 10.1021/bi1013672 DNA cleavage
2001 N Carmi R R Breaker Characterization of a DNA-cleaving deoxyribozyme. 11557347 10.1016/S0968-0896(01)00035-9 DNA cleavage
2013 A K Behera A Baum Enhanced deoxyribozyme‐catalyzed RNA ligation in the presence of organic cosolvents None 10.1002/bip.22191 RNA ligation
2012 V Dokukin S K Silverman Lanthanide ions as required cofactors for DNA catalysts None 10.1039/C2SC01067D DNA cleavage
2013 F Javadi-Zarnaghi Lanthanide cofactors accelerate DNA-catalyzed synthesis of branched RNA. 23895365 10.1021/ja406162z RNA ligation
2003 Z Liu Y Li Assemblage of signaling DNA enzymes with intriguing metal-ion specificities and pH dependences. 12812493 10.1021/ja035208+ RNA cleavage
2020 H Rosenbach I Span Molecular Features and Metal Ions That Influence 10-23 DNAzyme Activity. 32646019 10.3390/molecules25133100
2005 J C Achenbach Y Li Secondary-structure characterization of two proficient kinase deoxyribozymes. 15751953 10.1021/bi0483054 DNA phosphorylation
2009 K Schlosser Y Li DNAzyme-mediated catalysis with only guanosine and cytidine nucleotides. 19050014 10.1093/nar/gkn930 RNA cleavage
2003 M J Cairns L‐Q Sun Optimisation of the 10-23 DNAzyme-substrate pairing interactions enhanced RNA cleavage activity at purine-cytosine target sites. 12771215 10.1093/nar/gkg378 RNA cleavage
2005 A Peracchi M Clerici A mutational analysis of the 8-17 deoxyribozyme core. 16125199 10.1016/j.jmb.2005.07.059 RNA cleavage
2008 K Schlosser Y Li Sequence-function relationships provide new insight into the cleavage site selectivity of the 8–17 RNA-cleaving deoxyribozyme None 10.1093/nar/gkm1175 RNA cleavage
2004 R P.G Cruz Y Li Dinucleotide Junction Cleavage Versatility of 8-17 Deoxyribozyme None 10.1016/j.chembiol.2003.12.012 RNA cleavage
2008 K Schlosser J Gu, L Sule Sequence-function relationships provide new insight into the cleavage site selectivity of the 8-17 RNA-cleaving deoxyribozyme None 10.1093/nar/gkm1175 RNA cleavage
2019 E J Mattioli M Calvaresi DNAzymes at Work: A DFT Computational Investigation on the Mechanism of 9DB1 None 10.1021/acs.jcim.8b00815 RNA ligation
2017 R Saran J Liu A Silver-Specific DNAzyme with a New Silver Aptamer and Salt-Promoted Activity. 28345892 10.1021/acs.biochem.6b01131 RNA cleavage
2013 H Gu R R Breaker Small, highly active DNAs that hydrolyze DNA. 23679108 10.1021/ja403585e DNA cleavage
2009 A K Brown Y Lu Biochemical characterization of a uranyl ion-specific DNAzyme. 19142882 10.1002/cbic.200800632 RNA cleavage
2005 K E Nelson Y Lu In vitro selection of high temperature Zn(2+)-dependent DNAzymes. 16096680 10.1007/s00239-004-0374-3 RNA cleavage
2014 P-J J Huang J Liu Ultrasensitive DNAzyme beacon for lanthanides and metal speciation. 24383540 10.1021/ac403762s RNA cleavage
2017 W Zhou J Liu Two Completely Different Mechanisms for Highly Specific Na+ Recognition by DNAzymes None 10.1002/cbic.201700184 RNA cleavage
2014 P-J J Huang J Liu In vitro selection of a new lanthanide-dependent DNAzyme for ratiometric sensing lanthanides. 25199650 10.1021/ac5029962 RNA cleavage
2016 W Zhou J Liu A DNAzyme requiring two different metal ions at two distinct sites. 26657636 10.1093/nar/gkv1346 RNA cleavage
2011 M M Ali Y Li Fluorogenic DNAzyme probes as bacterial indicators. 21412961 10.1002/anie.201100477 RNA cleavage
2002 L Lermer D M Perrin Toward an RNaseA mimic: A DNAzyme with imidazoles and cationic amines. 12188639 10.1021/ja0205075 RNA cleavage
2014 M Wang Z Tang In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity. 25030901 10.1093/nar/gku592 DNA cleavage
2010 J C F Lam Y Li A complex RNA-cleaving DNAzyme that can efficiently cleave a pyrimidine-pyrimidine junction. 20630470 10.1016/j.jmb.2010.05.047 RNA cleavage
2009 M Hollenstein D M Perrin A DNAzyme with three protein-like functional groups: enhancing catalytic efficiency of M2+-independent RNA cleavage. 19591189 10.1002/cbic.200900314 RNA cleavage
2015 S-F Torabi Y Lu In vitro selection of a sodium-specific DNAzyme and its application in intracellular sensing None 10.1073/pnas.1420361112 RNA cleavage
2019 L Ma J Liu From general base to general acid catalysis in a sodium-specific DNAzyme by a guanine-to-adenine mutation None 10.1093/nar/gkz578 RNA cleavage
2019 L Ma J Liu An in Vitro-Selected DNAzyme Mutant Highly Specific for Na under Slightly Acidic Conditions. 29989277 10.1002/cbic.201800322 RNA cleavage
2015 S-F Torabi Y Lu Identification of the Same Na(+)-Specific DNAzyme Motif from Two In Vitro Selections Under Different Conditions. 26577294 10.1007/s00239-015-9715-7 RNA cleavage
2003 S H J Mei Y Li An efficient RNA-cleaving DNA enzyme that synchronizes catalysis with fluorescence signaling. 12517153 10.1021/ja0281232 RNA cleavage
2007 J Liu Y Lu A catalytic beacon sensor for uranium with parts-per-trillion sensitivity and millionfold selectivity. 17284609 10.1073/pnas.0607875104 RNA cleavage
2011 C J Hipolito D M Perrin Protein-inspired modified DNAzymes: dramatic effects of shortening side-chain length of 8-imidazolyl modified deoxyadenosines in selecting RNaseA mimicking DNAzymes. 21311779 10.1039/c0ob00595a RNA cleavage
2016 W Zhou J Liu An Efficient Lanthanide-Dependent DNAzyme Cleaving 2'-5'-Linked RNA. 26957420 10.1002/cbic.201500690 RNA cleavage
2016 Z Shen Y Li A Catalytic DNA Activated by a Specific Strain of Bacterial Pathogen. 26676768 10.1002/anie.201510125 RNA cleavage
2015 R Saran J Liu Searching for a DNAzyme Version of the Leadzyme. 26458991 10.1007/s00239-015-9702-z RNA cleavage
2013 P Wu Y Lu A DNAzyme-gold nanoparticle probe for uranyl ion in living cells. 23531046 10.1021/ja400150v RNA cleavage
2019 Y Wang H Yu A Novel Small RNA-Cleaving Deoxyribozyme with a Short Binding Arm None 10.1038/s41598-019-44750-x RNA cleavage
2013 M Hollenstein D M Perrin Toward the combinatorial selection of chemically modified DNAzyme RNase A mimics active against all-RNA substrates. 23485334 10.1021/co3001378 RNA cleavage
2001 D M Perrin C Hélène Bridging the gap between proteins and nucleic acids: a metal-independent RNAseA mimic with two protein-like functionalities. 11456753 10.1021/ja003290s RNA cleavage
2009 M Hollenstein D M Perrin A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+). 19153138 10.1093/nar/gkn1070 RNA cleavage
2020 C P M Scheitl C Höbartner New Deoxyribozymes for the Native Ligation of RNA. 32796587 10.3390/molecules25163650 RNA ligation
1999 Y Li R R Breaker Phosphorylating DNA with DNA. 10077582 10.1073/pnas.96.6.2746 DNA phosphorylation
2018 L Gu J Liu Reselection Yielding a Smaller and More Active Silver-Specific DNAzyme. 31458180 10.1021/acsomega.8b02039 RNA cleavage
2016 P-J J Huang J Liu Distinction of Individual Lanthanide Ions with a DNAzyme Beacon Array None 10.1021/acssensors.6b00239 RNA cleavage
2016 W Zhou J Liu In Vitro Selection of Chromium-Dependent DNAzymes for Sensing Chromium(III) and Chromium(VI). 27249536 10.1002/chem.201601426 RNA cleavage
2019 P-J J Huang J Liu Instantaneous Iodine-Assisted DNAzyme Cleavage of Phosphorothioate RNA. 30272443 10.1021/acs.biochem.8b00900 RNA cleavage
2015 M Vazin J Liu Biochemical Characterization of a Lanthanide-Dependent DNAzyme with Normal and Phosphorothioate-Modified Substrates. 26356231 10.1021/acs.biochem.5b00691 RNA cleavage
2015 P-J J Huang J Liu A new heavy lanthanide-dependent DNAzyme displaying strong metal cooperativity and unrescuable phosphorothioate effect. 25488814 10.1093/nar/gku1296 RNA cleavage
2015 P-J J Huang J Liu Desulfurization Activated Phosphorothioate DNAzyme for the Detection of Thallium. 26393365 10.1021/acs.analchem.5b02568 RNA cleavage
2016 P-J J Huang J Liu In Vitro Selection of a DNAzyme Cooperatively Binding Two Lanthanide Ions for RNA Cleavage. 27054549 10.1021/acs.biochem.6b00132 RNA cleavage
2015 W Zhou J Liu A New Na+‐Dependent RNA‐Cleaving DNAzyme with over 1000‐fold Rate Acceleration by Ethanol None 10.1002/cbic.201500603 RNA cleavage
2017 W Zhou J Liu An Exceptionally Selective DNA Cooperatively Binding Two Ca Ions. 28087991 10.1002/cbic.201600708 RNA cleavage
2018 T Yu J Liu An RNA-Cleaving Catalytic DNA Accelerated by Freezing. 29537685 10.1002/cbic.201800049 RNA cleavage
2016 P-J J Huang J Liu An Ultrasensitive Light-up Cu(2+) Biosensor Using a New DNAzyme Cleaving a Phosphorothioate-Modified Substrate. 26857405 10.1021/acs.analchem.5b04904 RNA cleavage
2015 P-J J Huang J Liu Rational evolution of Cd2+-specific DNAzymes with phosphorothioate modified cleavage junction and Cd2+ sensing. 25990730 10.1093/nar/gkv519 RNA cleavage
2020 W Ren J Liu Selection of a metal ligand modified DNAzyme for detecting Ni. 32510338 10.1016/j.bios.2020.112285 RNA cleavage
2015 Rachel Gysbers Y Li Evolution of an Enzyme from a Noncatalytic Nucleic Acid Sequence. 26091540 10.1038/srep11405 RNA cleavage
2000 S W Santoro C F Barbas RNA Cleavage by a DNA Enzyme with Extended Chemical Functionality None 10.1021/ja993688s RNA cleavage
2018 Y Wang D M Perrin A densely modified M2+-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover None 10.1039/C7SC04491G RNA cleavage
2020 P-J J Huang J Liu Target Self-Enhanced Selectivity in Metal-Specific DNAzymes. 31867832 10.1002/anie.201915675 RNA cleavage
2007 W Chiuman Y Li Simple fluorescent sensors engineered with catalytic DNA 'MgZ' based on a non-classic allosteric design. 18030352 10.1371/journal.pone.0001224 RNA cleavage
2004 M A Carrigan S A Benner Quantitative analysis of a RNA-cleaving DNA catalyst obtained via in vitro selection. 15350131 10.1021/bi049898l RNA cleavage
2006 W Chiuman Y Li Revitalization of six abandoned catalytic DNA species reveals a common three-way junction framework and diverse catalytic cores. 16480741 10.1016/j.jmb.2006.01.036 RNA cleavage
2006 W Chiuman Y Li Evolution of high-branching deoxyribozymes from a catalytic DNA with a three-way junction. 17052610 10.1016/j.chembiol.2006.08.009 RNA cleavage
2015 K Tram Y Li An Efficient Catalytic DNA that Cleaves L-RNA. 25946137 10.1371/journal.pone.0126402 RNA cleavage
2002 P Ordoukhanian G F Joyce RNA-cleaving DNA enzymes with altered regio- or enantioselectivity. 12381192 10.1021/ja027467p RNA cleavage
2004 K Schlosser Y Li Tracing sequence diversity change of RNA-cleaving deoxyribozymes under increasing selection pressure during in vitro selection. 15274624 10.1021/bi049757j RNA cleavage
2006 K Schlosser Y Li Characterization of long RNA-cleaving deoxyribozymes with short catalytic cores: the effect of excess sequence elements on the outcome of in vitro selection. 16682452 10.1093/nar/gkl276 RNA cleavage
2002 P J Bruesehoff Y Lu Improving metal ion specificity during in vitro selection of catalytic DNA. 12052183 10.2174/1386207023330264 RNA cleavage
2012 K E Nelson Y Lu The importance of peripheral sequences in determining the metal selectivity of an in vitro-selected Co(2+) -dependent DNAzyme. 22250000 10.1002/cbic.201100724 RNA cleavage
2008 K Schlosser Y Li In vitro selection of small RNA-cleaving deoxyribozymes that cleave pyrimidine-pyrimidine junctions. 18644842 10.1093/nar/gkn396 RNA cleavage
2001 A R Feldman D Sen A new and efficient DNA enzyme for the sequence-specific cleavage of RNA. 11800557 10.1006/jmbi.2001.5058 RNA cleavage
2004 A V Sidorov D M Williams Sequence-specific cleavage of RNA in the absence of divalent metal ions by a DNAzyme incorporating imidazolyl and amino functionalities. 15004246 10.1093/nar/gkh326 RNA cleavage
2019 L Yang R Pei Exploration of Catalytic Nucleic Acids on Porphyrin Metalation and Peroxidase Activity by in Vitro Selection of Aptamers for N-Methyl Mesoporphyrin IX. 30602113 10.1021/acscombsci.8b00129 Porphyrin metalation
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