DNAmoreDB - A Database of Deoxyribozymes

DNAzyme description

 Reaction  Reacting groups  Substrates  Metal ion Linkage  Seq description
RNA cleavage Group 1 - 2'-OH

Group 2 - vicinal phosphate

S: cleavage in cis
M2+-independent
RNA phosphodiester N 40
 Buffer conditions
50 mM sodium cacodylate pH 7.5, 200 mM NaCl, 1 mM EDTA
 Catalytic region of the DNAzyme
TTACAGTGGTATCGATTGGGACGTGTGGAGCGTCAGGATGGGATCA
Notes
Reselected from 7-38.

 Reported in...

Year of Publication First Author Laboratory Title PubMed ID DOI Reaction
2018 Y Wang D M Perrin A densely modified M2+-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover None 10.1039/C7SC04491G RNA cleavage

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