DNAmoreDB - A Database of Deoxyribozymes

DNAzyme description

 Reaction  Reacting groups  Substrates  Metal ion Linkage  Seq description
RNA cleavage Group 1 - 2'-OH of rA

Group 2 - vicinal phosphate

S: cleavage in cis
metal ion dependency not reported
RNA phosphodiester N 40
 Buffer conditions
50 mM Na.Hepes pH 7.0, 0.5 M NaCl, 10 mM Mg2+
 kcat/ kobs
kobs = 1.37 min-1
 Catalytic region of the DNAzyme
TCTCTTTCTGCAGAGGAGGTAGGGGTTCCGCTCCAAGGGC

 Reported in...

Year of Publication First Author Laboratory Title PubMed ID DOI Reaction
2001 A R Feldman D Sen A new and efficient DNA enzyme for the sequence-specific cleavage of RNA. 11800557 10.1006/jmbi.2001.5058 RNA cleavage

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