DNAmoreDB - A Database of Deoxyribozymes

DNAzyme description

 Reaction  Reacting groups  Substrates Product  Metal ion Linkage  Seq description
Covalent Modification of Amino Acid Side Chains Group 1 - Ser

Group 2 - 5'-triphosphate

L: DNA-C3-CSA tripeptide
R: GGAAGAGAUGGCGACGG
nucleopeptide linkage Mn2+
Mg2+
Ser-RNA N 40
 Buffer conditions
50 mM HEPES pH 7.5, 150 mM, NaCl, 2 mM KCl, 40 mM MgCl2, 20 mM MnCl2
 Catalytic region of the DNAzyme
CAAGGAGTGTTGGATAAACGCGGGTCGTGTTCAAAGGGATC
Notes
Strong activity with DNA-C<sub>3</sub>-CYA and DNA-HEG-CYA substrates

 Reported in...

Year of Publication First Author Laboratory Title PubMed ID DOI Reaction
2011 O Y Wong S K Silverman DNA-catalyzed covalent modification of amino acid side chains in tethered and free peptide substrates. 21510668 10.1021/bi200585n Covalent Modification of Amino Acid Side Chains

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