DNAmoreDB - A Database of Deoxyribozymes

Published on 2011 in Angew. Chem. Int. Ed. Engl. volume 50 issue 49.

PubMed ID: 21994131

DOI:10.1002/anie.201104976

Abstract:

A new reaction for DNA : DNA is shown to catalyze Ni2+‐dependent reductive amination involving the N2‐amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.



DNAzymes linked to this article:

Name Isolated sequence Length Reaction
8QA102 AAGGGGTAGTGCTAAACGTGAAGATGGTTTGGGTAATCTC      40 Reductive amination
8QA103 AATGGCAGTGAGAAACGTATGGTCACATGTATGTGGTCAC      40 Reductive amination
8QA107 AAGGGGTAGTGCCAAACGTGGAAACCTGTGGATAAGGTCC      40 Reductive amination
8QA111 GGGGGCCGCGATTAAATGTTGTCATGCAGCTCTCTGAGGC      40 Reductive amination
8QA115 AGGGGCAGTGCTAAACGTGTACAGACTAAAATGGTCTGTC      40 Reductive amination
8QA122 AAGGGGCACGTGCTAAACGTGGAAGGACTTCGGTTCTCCC      40 Reductive amination
8QA104 AGGGGTAGTGCCAAACGTGGCCTGGTTTGATGATTCGGCC      40 Reductive amination
8QA108 AAGGGGTAGTGCCAAACGTACGAAGGCTTCATTACCGACC      40 Reductive amination
8QA109 AAGAGGCACGTGCTAAACGTGGAAGGACTTCGGTTCTCCA      40 Reductive amination
8QA124 AAGGGGCAGTGCTAAACGTGGACAGGAATCATAAGTGTCA      40 Reductive amination
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