DNAmoreDB - A Database of Deoxyribozymes

Published on 2011 in Angew. Chem. Int. Ed. Engl. volume 50 issue 16.

PubMed ID: 21412961

DOI:10.1002/anie.201100477

Abstract:

Lighting up bacteria: An RNA‐cleaving fluorescent DNAzyme (RFD) can produce a fluorescent signal in the crude extracellular mixture generated by live bacterial cells (see picture). These DNAzymes cleave a lone RNA linkage (R) embedded in a DNA chain and flanked by nucleotides labeled with a fluorophore (F) and a quencher (Q).



DNAzymes linked to this article:

Name Isolated sequence Length Reaction
RFD-EC1 CACGGATCCTGACAAGGATGTGTGCGTTGTCGAGACCTGCGACCGGAACACTACACTGTGTGGGATGGATTTCTTTACAGTTGTGTGCAGCTCCGTCCGACTCTTCCTAGCFRQGGTTCGATCAAGA      127 RNA cleavage
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